DegronMD

Uniprot ID: Q9Y5X1

Source protein: Sorting nexin-9

Source gene: SNX9

Class: DEG_SCF_FBW7_1

Location: 274:279

E3 ligase: FBXW7

DEGRON score: 0.7686

ASA_SCORE: 77.25

COIL: 0.7245

CONS_SCORE: 0.501

DSS_SCORE: 0.2777

HELIX: 0.0177

FCONS_SCORE: 0.8493

RIG_SCORE: 0.7784

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R281Q	TCGA-B5-A11E	UCEC	TCGA	LTPTNT	DEG_SCF_FBW7_1	0.2778
p.R281Q	DO41644	UCEC	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.2778
p.R281Q	SIDM00193	Colorectal Carcinoma	GDSC	LTPTNT	DEG_SCF_FBW7_1	0.2778
p.R281Q	ACH-000991	Colon/Colorectal Cancer	CCLE	LTPTNT	DEG_SCF_FBW7_1	0.2778
p.R281Q	SNU-81	large_intestine	COSMIC	LTPTNT	DEG_SCF_FBW7_1	0.2778
p.N280S	TCGA-CQ-6221	HNSC	TCGA	LTPTNT	DEG_SCF_FBW7_1	0.3056
p.N280S	DO14622	HNSC	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.3056
p.L266I	TCGA-D3-A2JP	SKCM	TCGA	LTPTNT	DEG_SCF_FBW7_1	0.1111
p.L266I	DO47407	SKCM	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.1111
p.R286M	TCGA-DU-6392	LGG	TCGA	LTPTNT	DEG_SCF_FBW7_1	0.1389
p.R286M	DO22237	LGG	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.1389
p.R281L	TCGA-KQ-A41N	BLCA	TCGA	LTPTNT	DEG_SCF_FBW7_1	0.2778
p.R281L	DO223588	BLCA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.2778
p.H285R	DO222849	COCA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.1667
p.S268I	DO229006	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.1667
p.R286W	DO231078	LUSC	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.1389
p.E271K	DO228338	MALY	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.25
p.E271K	SIDM00217	Colorectal Carcinoma	GDSC	LTPTNT	DEG_SCF_FBW7_1	0.25
p.E271K	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPTNT	DEG_SCF_FBW7_1	0.25
p.E271K	SNU-1040	large_intestine	COSMIC	LTPTNT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons