DegronMD

Uniprot ID: Q5T7N8

Source protein: Protein FAM27D1

Source gene: FAM27D1

Class: DEG_SCF_FBW7_1

Location: 183:188

E3 ligase: FBXW7

DEGRON score: 0.8532

ASA_SCORE: 71.9

COIL: 0.6802

CONS_SCORE: 0.0999

DSS_SCORE: 0.4033

HELIX: 0.1648

FCONS_SCORE: 1

RIG_SCORE: 0.7538

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R182L	DO228945	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.3056
p.R182L	DO229058	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.3056
p.S189F	DO228947	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.3056
p.P194S	DO229058	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.1667
p.P196S	DO228950	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.1111
p.P196S	DO228960	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.1111
p.P196S	DO229056	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.1111
p.P196S	DO229057	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.1111
p.G173E	DO228941	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.0556
p.G173E	DO229006	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons