DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPTNT
Uniprot ID:
Q5T7N8
Source protein:
Protein FAM27D1
Source gene:
FAM27D1
Class:
DEG_SCF_FBW7_1
Location:
183:188
E3 ligase:
FBXW7
DEGRON score:
0.8532
ASA_SCORE:
71.9
COIL:
0.6802
CONS_SCORE:
0.0999
DSS_SCORE:
0.4033
HELIX:
0.1648
FCONS_SCORE:
1
RIG_SCORE:
0.7538
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G173E
DO228941
LICA
ICGC
LTPTNT
DEG_SCF_FBW7_1
0.0556
p.G173E
DO229006
LICA
ICGC
LTPTNT
DEG_SCF_FBW7_1
0.0556
p.R182L
DO228945
LICA
ICGC
LTPTNT
DEG_SCF_FBW7_1
0.3056
p.R182L
DO229058
LICA
ICGC
LTPTNT
DEG_SCF_FBW7_1
0.3056
p.S189F
DO228947
LICA
ICGC
LTPTNT
DEG_SCF_FBW7_1
0.3056
p.P196S
DO228950
LICA
ICGC
LTPTNT
DEG_SCF_FBW7_1
0.1111
p.P196S
DO228960
LICA
ICGC
LTPTNT
DEG_SCF_FBW7_1
0.1111
p.P196S
DO229056
LICA
ICGC
LTPTNT
DEG_SCF_FBW7_1
0.1111
p.P196S
DO229057
LICA
ICGC
LTPTNT
DEG_SCF_FBW7_1
0.1111
p.P194S
DO229058
LICA
ICGC
LTPTNT
DEG_SCF_FBW7_1
0.1667
Drug responses associated with FAM27D1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPTNT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y5X1
Sorting nexin-9
DEG_SCF_FBW7_1
274:279
LTPTNT
FBXW7
0.7686
More...
Q5T7N8
Protein FAM27D1
DEG_SCF_FBW7_1
183:188
LTPTNT
FBXW7
0.8532
More...