DegronMD - Q96QS3(ARX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V561L	TCGA-2Y-A9HA	LIHC	TCGA	PGTST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.V561L	DO219539	LIHC	ICGC	PGTST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.E560D	TCGA-D1-A103	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.25
p.E560D	DO42312	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.25
p.E61K	TCGA-EE-A3AE	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1389
p.E61K	DO37802	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1389
p.A544V	DO225160	BRCA	ICGC	PGTST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0833
p.A544V	DO227862	BRCA	ICGC	PGTST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0833
p.A425E	DO229355	BTCA	ICGC	LSPYLD	LIG_APCC_ABBA_1	410:415	Mutation rewiring degron network	0.0556
p.A499T	DO233089	GACA	ICGC	PTPAVE	DEG_SCF_FBW7_2	504:509	Mutation rewiring degron network	0.1944
p.P403T	DO229026	LICA	ICGC	LSPYLD	LIG_APCC_ABBA_1	410:415	Mutation rewiring degron network	0.1389
p.Q65K	DO229026	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.A516D	DO229037	LICA	ICGC	PTPAVE	DEG_SCF_FBW7_2	504:509	Mutation rewiring degron network	0.1389
p.L552P	DO38404	STAD	ICGC	PGTST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.3056
p.D415G	DO229208	THCA	ICGC	LSPYLD	LIG_APCC_ABBA_1	410:415	Mutation altering degron motif	0.7198
p.V561E	DO229213	THCA	ICGC	PGTST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.A543S	DO229227	THCA	ICGC	PGTST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0556
p.K62N	DO229232	THCA	ICGC	PKSSS	DEG_SPOP_SBC_1	68:72	Mutation substituting flanking lysine	0.2778
p.R502K	SIDM01112	Osteosarcoma	GDSC	PTPAVE	DEG_SCF_FBW7_2	504:509	Mutation rewiring degron network	0.2778

Kaplan plot for ARX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARX

UniProt ID: Q96QS3

Entrez ID: 170302

Protein name: Homeobox protein ARX (Aristaless-related homeobox)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARX in