DegronMD

Uniprot ID: Q96QS3

Source protein: Homeobox protein ARX

Source gene: ARX

Class: DEG_SCF_FBW7_2

Location: 504:509

E3 ligase: FBXW7

DEGRON score: 0.8412

ASA_SCORE: 73.15

COIL: 0.8852

CONS_SCORE: 0.3466

DSS_SCORE: 0.2942

HELIX: 0.0705

FCONS_SCORE: 1.0189

RIG_SCORE: 0.7319

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A499T	DO233089	GACA	ICGC	PTPAVE	DEG_SCF_FBW7_2	0.1944
p.A516D	DO229037	LICA	ICGC	PTPAVE	DEG_SCF_FBW7_2	0.1389
p.R502K	SIDM01112	Osteosarcoma	GDSC	PTPAVE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QS3	Homeobox protein ARX	DEG_SCF_FBW7_2	504:509	PTPAVE	FBXW7	0.8412	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons