DegronMD

Uniprot ID: Q15811

Source protein: Intersectin-1

Source gene: ITSN1

Class: DEG_SPOP_SBC_1

Location: 180:184

E3 ligase: SPOP

DEGRON score: 0.9976

ASA_SCORE: 74.62

COIL: 0.9044

CONS_SCORE: 0.3044

DSS_SCORE: 0.5665

HELIX: 0.0564

FCONS_SCORE: 1.0514

RIG_SCORE: 0.6344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S188C	TCGA-AP-A054	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.6667
p.S188C	DO42256	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.6667
p.R187S	TCGA-AX-A2HA	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.25
p.R187S	DO42504	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.25
p.S188Y	TCGA-CN-A49A	HNSC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.6667
p.S188Y	DO52042	HNSC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.6667
p.A176S	TCGA-D3-A2JP	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	0.2222
p.A176S	DO47407	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	0.2222
p.A171V	DO230309	COCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0833
p.P175T	DO229268	THCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1944
p.R187K	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.25
p.R187K	ACH-002264	Esophageal Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.25
p.R187K	KYSE-50	oesophagus	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.25
p.Q182R	RKO	large_intestine	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.7329
p.L179Q	LNCaP-Clone-FGC	prostate	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.3056
p.R189M	NCI-H2227	lung	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.1944
p.R189S	CAL-12T	lung	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15085	Rho guanine nucleotide exchange factor 11	DEG_SPOP_SBC_1	543:547	PKSSS	SPOP	0.7465	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1015:1019	PKSSS	SPOP	0.8719	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	564:568	PKSSS	SPOP	0.9922	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	289:293	PKSSS	SPOP	0.9956	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	180:184	PKSSS	SPOP	0.9976	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	225:229	PKSSS	SPOP	0.9834	More...
Q5TCZ1	SH3 and PX domain-containing protein 2A	DEG_SPOP_SBC_1	663:667	PKSSS	SPOP	0.8452	More...
Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	DEG_SPOP_SBC_1	89:93	PKSSS	SPOP	0.7468	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	200:204	PKSSS	SPOP	0.9805	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	534:538	PKSSS	SPOP	0.9952	More...
Q8WYP5	Protein ELYS	DEG_SPOP_SBC_1	1340:1344	PKSSS	SPOP	0.9617	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	68:72	PKSSS	SPOP	0.583	More...
Q9NXV6	CDKN2A-interacting protein	DEG_SPOP_SBC_1	347:351	PKSSS	SPOP	0.9905	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1710:1714	PKSSS	SPOP	0.9961	More...
Q9Y5X1	Sorting nexin-9	DEG_SPOP_SBC_1	172:176	PKSSS	SPOP	0.9854	More...
A6NHQ2	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1	DEG_SPOP_SBC_1	329:333	PKSSS	SPOP	0.72	More...
A7E2F4	Golgin subfamily A member 8A	DEG_SPOP_SBC_1	83:87	PKSSS	SPOP	0.7895	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	20:24	PKSSS	SPOP	0.8424	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	96:100	PKSSS	SPOP	0.8516	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	544:548	PKSSS	SPOP	0.9953	More...
Q9BX69	Caspase recruitment domain-containing protein 6	DEG_SPOP_SBC_1	1012:1016	PKSSS	SPOP	0.9263	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	434:438	PKSSS	SPOP	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKSSS

Degron related mutations and impact score

Drug responses associated with ITSN1 mutations

All proteins holding degron of PKSSS