DegronMD - P52594(AGFG1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V434M	TCGA-19-5956	GBM	TCGA	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.0556
p.A453G	TCGA-22-1012	LUSC	TCGA	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1944
p.V428F	TCGA-79-5596	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1667
p.S406N	TCGA-A5-A0G2	UCEC	TCGA	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.0833
p.S298I	TCGA-AA-A00N	COAD	TCGA	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation blocking phosphorylation signal	0.6389
p.T151A	TCGA-BG-A222	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.825
p.T151A	DO42977	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.825
p.A148V	TCGA-CA-6718	COAD	TCGA	ASSTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.5825
p.A148V	DO7801	COAD	ICGC	ASSTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.5825
p.A299D	TCGA-EA-A3HU	CESC	TCGA	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1667
p.P388S	TCGA-EB-A5UN	SKCM	TCGA	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1944
p.P388S	DO42793	UCEC	ICGC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1944
p.S410Y	TCGA-EM-A4FN	THCA	TCGA	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1111
p.T454M	TCGA-IB-7651	PAAD	TCGA	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1667
p.F451C	TCGA-W5-AA39	CHOL	TCGA	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.25
p.A417V	TCGA-XK-AAIW	PRAD	TCGA	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.3056
p.S422F	DO44242	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.7982
p.S422F	DO41488	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.7982
p.A294G	DO219629	BRCA	ICGC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.M449I	DO8842	COAD	ICGC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.3056
p.T451I	DO230342	COCA	ICGC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.25
p.A419G	DO222769	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.6429
p.A419G	DO42480	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.6429
p.S425A	DO219918	DLBC	ICGC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.25
p.S152R	DO234197	ESAD	ICGC	ASSTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7427
p.N287D	DO234443	ESAD	ICGC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2778
p.M447L	DO233034	GACA	ICGC	VASST	DEG_SPOP_SBC_1	444:448	Mutation altering degron motif	0.711
p.A141G	DO233203	GACA	ICGC	ASSTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1389
p.V389M	DO13863	GBM	ICGC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.2222
p.A288S	DO229019	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.C280F	DO229015	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.0833
p.Q303H	DO229015	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.0556
p.A417S	DO229031	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.3056
p.V402L	DO229008	LICA	ICGC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1944
p.H284L	DO52318	LIHC	ICGC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944
p.T395A	DO23210	LINC	ICGC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation altering degron motif	0.7139
p.A393V	DO231620	LINC	ICGC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation altering degron motif	0.5825
p.V383F	DO27357	LUSC	ICGC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.0556
p.A408G	DO27302	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.D295N	DO219199	LUSC	ICGC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2778
p.A457P	DO219178	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.0833
p.N281T	DO46334	OV	ICGC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1111
p.T409M	DO46657	PAAD	ICGC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.T432I	DO32964	PACA	ICGC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.S448G	DO47743	STAD	ICGC	VASST	DEG_SPOP_SBC_1	444:448	Mutation altering degron motif	0.6993
p.P456L	DO42097	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1111
p.M449T	DO42913	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.3056
p.A300G	SIDM00845	Burkitt's Lymphoma	GDSC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1389
p.A300G	SIDM00035	Thyroid Gland Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1389
p.A300G	SIDM01519	Head and Neck Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1389
p.A300G	Daudi	haematopoietic and lymphoid tissue	COSMIC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1389
p.Q390H	SIDM00845	Burkitt's Lymphoma	GDSC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.25
p.A399V	SIDM01062	Breast Carcinoma	GDSC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.2778
p.A399V	HDQ-P1	breast	COSMIC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.2778
p.N458I	SIDM00533	Pancreatic Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.0556
p.N458I	HuP-T3	pancreas	COSMIC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.0556
p.F282S	SIDM01039	Other Solid Cancers	GDSC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1389
p.L291V	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.6765
p.L291V	NCI-H2009	lung	COSMIC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.6765
p.A402V	SIDM00783	Colorectal Carcinoma	GDSC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1944
p.A402V	HCT-116	large intestine	COSMIC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1944
p.P456A	ACH-000136	Neuroblastoma	CCLE	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1111
p.P456A	CHP-126	autonomic ganglia	COSMIC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1111
p.Q431H	ACH-000588	Myeloma	CCLE	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.Q431H	ACH-002201	Cervical Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.Q431H	TC-YIK	cervix	COSMIC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.S302P	ACH-000950	Colon/Colorectal Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation blocking phosphorylation signal	0.5278
p.S302P	LoVo	large intestine	COSMIC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation blocking phosphorylation signal	0.5278
p.F415C	ACH-001081	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.25
p.F415C	HCC2998	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.25
p.Q452H	TC-YIK	cervix	COSMIC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.2222
p.A420V	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.6936
p.N300S	S-117	soft tissue	COSMIC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1389
p.N434I	HuP-T3	pancreas	COSMIC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.0556
p.P439S	Sarc9371	bone	COSMIC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1944
p.G300R	COLO-829	skin	COSMIC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1389
p.N394I	HuP-T3	pancreas	COSMIC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation altering degron motif	0.728
p.N413I	HuP-T3	pancreas	COSMIC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1944
p.P458S	Sarc9371	bone	COSMIC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.0556
p.P437A	CHP-126	autonomic ganglia	COSMIC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1389
p.F396C	HCC2998	large intestine	COSMIC	AYTST	DEG_SPOP_SBC_1	393:397	Mutation altering degron motif	0.7108
p.A439V	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1944
p.Q412H	TC-YIK	cervix	COSMIC	PASSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1667
p.K290E	LNCaP-Clone-FGC	prostate	COSMIC	PKSSS	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.591
p.F436C	HCC2998	large intestine	COSMIC	VASST	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGFG1

UniProt ID: P52594

Entrez ID: 3267

Protein name: Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for AGFG1 in