DegronMD

Uniprot ID: P52594

Source protein: Arf-GAP domain and FG repeat-containing protein 1

Source gene: AGFG1

Class: DEG_SPOP_SBC_1

Location: 393:397

E3 ligase: SPOP

DEGRON score: 0.8326

ASA_SCORE: 70.7

COIL: 0.904

CONS_SCORE: 0.2764

DSS_SCORE: 0.2805

HELIX: 0.0582

FCONS_SCORE: 0.8866

RIG_SCORE: 0.6914

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S406N	TCGA-A5-A0G2	UCEC	TCGA	AYTST	DEG_SPOP_SBC_1	0.0833
p.P388S	TCGA-EB-A5UN	SKCM	TCGA	AYTST	DEG_SPOP_SBC_1	0.1944
p.P388S	DO42793	UCEC	ICGC	AYTST	DEG_SPOP_SBC_1	0.1944
p.V389M	DO13863	GBM	ICGC	AYTST	DEG_SPOP_SBC_1	0.2222
p.V402L	DO229008	LICA	ICGC	AYTST	DEG_SPOP_SBC_1	0.1944
p.T395A	DO23210	LINC	ICGC	AYTST	DEG_SPOP_SBC_1	0.7139
p.A393V	DO231620	LINC	ICGC	AYTST	DEG_SPOP_SBC_1	0.5825
p.V383F	DO27357	LUSC	ICGC	AYTST	DEG_SPOP_SBC_1	0.0556
p.Q390H	SIDM00845	Burkitt's Lymphoma	GDSC	AYTST	DEG_SPOP_SBC_1	0.25
p.A399V	SIDM01062	Breast Carcinoma	GDSC	AYTST	DEG_SPOP_SBC_1	0.2778
p.A399V	HDQ-P1	breast	COSMIC	AYTST	DEG_SPOP_SBC_1	0.2778
p.A402V	SIDM00783	Colorectal Carcinoma	GDSC	AYTST	DEG_SPOP_SBC_1	0.1944
p.A402V	HCT-116	large_intestine	COSMIC	AYTST	DEG_SPOP_SBC_1	0.1944
p.N394I	HuP-T3	pancreas	COSMIC	AYTST	DEG_SPOP_SBC_1	0.728
p.F396C	HCC2998	large_intestine	COSMIC	AYTST	DEG_SPOP_SBC_1	0.7108

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	393:397	AYTST	SPOP	0.8326	More...
B4DS77	Protein shisa-9	DEG_SPOP_SBC_1	361:365	AYTST	SPOP	0.9983	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	642:646	AYTST	SPOP	0.9134	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons