DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_SPOP_SBC_1

Location: 642:646

E3 ligase: SPOP

DEGRON score: 0.9134

ASA_SCORE: 82.18

COIL: 0.9048

CONS_SCORE: 0.3765

DSS_SCORE: 0.2761

HELIX: 0.017

FCONS_SCORE: 0.744

RIG_SCORE: 0.7497

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y643H	TCGA-A5-A0G2	UCEC	TCGA	AYTST	DEG_SPOP_SBC_1	0.6118
p.L652S	TCGA-AX-A0J1	UCEC	TCGA	AYTST	DEG_SPOP_SBC_1	0.1667
p.G640C	TCGA-D3-A2JP	SKCM	TCGA	AYTST	DEG_SPOP_SBC_1	0.2778
p.A637S	DO20875	KIRP	ICGC	AYTST	DEG_SPOP_SBC_1	0.1944
p.S645N	DO23690	LUAD	ICGC	AYTST	DEG_SPOP_SBC_1	0.7069
p.S645G	DO31230	OV	ICGC	AYTST	DEG_SPOP_SBC_1	0.6993
p.S655Y	DO46657	PAAD	ICGC	AYTST	DEG_SPOP_SBC_1	0.0833
p.P653S	DO37515	SKCM	ICGC	AYTST	DEG_SPOP_SBC_1	0.1389
p.P653S	K2	skin	COSMIC	AYTST	DEG_SPOP_SBC_1	0.1389
p.P653L	DO41235	UCEC	ICGC	AYTST	DEG_SPOP_SBC_1	0.1389
p.G640A	SIDM00121	T-Lymphoblastic Leukemia	GDSC	AYTST	DEG_SPOP_SBC_1	0.2778
p.G640A	ACH-001738	Leukemia	CCLE	AYTST	DEG_SPOP_SBC_1	0.2778
p.G640A	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	AYTST	DEG_SPOP_SBC_1	0.2778
p.T638I	ACH-001097	Lymphoma	CCLE	AYTST	DEG_SPOP_SBC_1	0.2222
p.L654R	SiHa	cervix	COSMIC	AYTST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	393:397	AYTST	SPOP	0.8326	More...
B4DS77	Protein shisa-9	DEG_SPOP_SBC_1	361:365	AYTST	SPOP	0.9983	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	642:646	AYTST	SPOP	0.9134	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons