DegronMD

Uniprot ID: B4DS77

Source protein: Protein shisa-9

Source gene: SHISA9

Class: DEG_SPOP_SBC_1

Location: 361:365

E3 ligase: SPOP

DEGRON score: 0.9983

ASA_SCORE: 52.18

COIL: 0.7264

CONS_SCORE: 0.316

DSS_SCORE: 0.6166

HELIX: 0.1502

FCONS_SCORE: 1.0528

RIG_SCORE: 0.7049

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F368L	TCGA-L5-A4OU	ESCA	TCGA	AYTST	DEG_SPOP_SBC_1	0.25
p.L360P	DO24860	LUAD	ICGC	AYTST	DEG_SPOP_SBC_1	0.3056
p.N353H	DO50720	ORCA	ICGC	AYTST	DEG_SPOP_SBC_1	0.1111
p.R351S	SIDM02045	Colorectal Carcinoma	GDSC	AYTST	DEG_SPOP_SBC_1	0.0556
p.L360V	SIDM02071	Esophageal Carcinoma	GDSC	AYTST	DEG_SPOP_SBC_1	0.3056
p.R351L	SIDM00760	Small Cell Lung Carcinoma	GDSC	AYTST	DEG_SPOP_SBC_1	0.0556
p.R351L	ACH-000729	Lung Cancer	CCLE	AYTST	DEG_SPOP_SBC_1	0.0556
p.R351L	NCI-H1963	lung	COSMIC	AYTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	393:397	AYTST	SPOP	0.8326	More...
B4DS77	Protein shisa-9	DEG_SPOP_SBC_1	361:365	AYTST	SPOP	0.9983	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	642:646	AYTST	SPOP	0.9134	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons