p.A520P | TCGA-05-4427 | LUAD | TCGA | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.2222 |
p.P797R | TCGA-25-2398 | OV | TCGA | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation altering degron motif | 0.7512 |
p.S522L | TCGA-2Y-A9H5 | LIHC | TCGA | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.2778 |
p.P214S | TCGA-37-5819 | LUSC | TCGA | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation altering degron motif | 0.6752 |
p.P233S | TCGA-38-A44F | LUAD | TCGA | PPPY | ITCH | 233:236 | Mutation altering degron motif | 0.6752 |
p.A745S | TCGA-52-7810 | LUSC | TCGA | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation rewiring degron network | 0.0833 |
p.A520S | TCGA-53-7813 | LUAD | TCGA | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.2222 |
p.G540V | TCGA-69-7978 | LUAD | TCGA | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.0556 |
p.G540V | TCGA-69-7978 | LUAD | TCGA | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.1667 |
p.Y643H | TCGA-A5-A0G2 | UCEC | TCGA | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation altering degron motif | 0.6118 |
p.G370C | TCGA-A5-A0G2 | UCEC | TCGA | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation rewiring degron network | 0.0833 |
p.G370C | TCGA-A5-A0G2 | UCEC | TCGA | PTPGPT | DEG_SCF_FBW7_1 | 380:385 | Mutation rewiring degron network | 0.0556 |
p.G370C | TCGA-BF-A1Q0 | SKCM | TCGA | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation rewiring degron network | 0.0833 |
p.G370C | TCGA-BF-A1Q0 | SKCM | TCGA | PTPGPT | DEG_SCF_FBW7_1 | 380:385 | Mutation rewiring degron network | 0.0556 |
p.H209R | TCGA-AA-A02E | COAD | TCGA | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.25 |
p.S352N | TCGA-AD-6889 | COAD | TCGA | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation altering degron motif | 0.7069 |
p.S775P | TCGA-AJ-A3EL | UCEC | TCGA | PLSSS | DEG_SPOP_SBC_1 | 780:784 | Mutation rewiring degron network | 0.1944 |
p.V719A | TCGA-AP-A1DK | UCEC | TCGA | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.1111 |
p.P202L | TCGA-AX-A06F | UCEC | TCGA | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.0556 |
p.P202L | TCGA-AX-A2HD | UCEC | TCGA | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.0556 |
p.P807L | TCGA-AX-A06H | UCEC | TCGA | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation rewiring degron network | 0.1389 |
p.L652S | TCGA-AX-A0J1 | UCEC | TCGA | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.1667 |
p.H593Y | TCGA-B5-A3FA | UCEC | TCGA | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation rewiring degron network | 0.3056 |
p.G540D | TCGA-B5-A3FC | UCEC | TCGA | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.0556 |
p.G540D | TCGA-B5-A3FC | UCEC | TCGA | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.1667 |
p.P722T | TCGA-BH-A0AW | BRCA | TCGA | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.1944 |
p.P722T | TCGA-BH-A0AW | BRCA | TCGA | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation rewiring degron network | 0.0556 |
p.I726T | TCGA-CA-6717 | COAD | TCGA | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.3056 |
p.I726T | TCGA-CA-6717 | COAD | TCGA | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation rewiring degron network | 0.1667 |
p.P270A | TCGA-CR-6481 | HNSC | TCGA | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation rewiring degron network | 0.1944 |
p.L537M | TCGA-D1-A103 | UCEC | TCGA | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.1389 |
p.L537M | TCGA-D1-A103 | UCEC | TCGA | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.0833 |
p.K290N | TCGA-D3-A2JK | SKCM | TCGA | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation substituting flanking lysine | 0.1944 |
p.G640C | TCGA-D3-A2JP | SKCM | TCGA | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.2778 |
p.P275H | TCGA-D9-A149 | SKCM | TCGA | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation altering degron motif | 0.7694 |
p.T326I | TCGA-DI-A1BU | UCEC | TCGA | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation altering degron motif | 0.7078 |
p.S720F | TCGA-E6-A1M0 | UCEC | TCGA | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.1389 |
p.A523S | TCGA-EA-A3HS | CESC | TCGA | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.3056 |
p.S269P | TCGA-EB-A51B | SKCM | TCGA | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation rewiring degron network | 0.1667 |
p.H271N | TCGA-EE-A20F | SKCM | TCGA | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation rewiring degron network | 0.2222 |
p.P270S | TCGA-EE-A29D | SKCM | TCGA | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation rewiring degron network | 0.1944 |
p.G588S | TCGA-EE-A2MI | SKCM | TCGA | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation rewiring degron network | 0.1667 |
p.Q528H | TCGA-EE-A2MM | SKCM | TCGA | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation altering degron motif | 0.647 |
p.P284S | TCGA-EE-A2MR | SKCM | TCGA | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation rewiring degron network | 0.25 |
p.Y519H | TCGA-EI-6882 | READ | TCGA | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.1944 |
p.A226V | TCGA-EO-A22U | UCEC | TCGA | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.3056 |
p.A226V | TCGA-EO-A22U | UCEC | TCGA | PPPY | ITCH | 233:236 | Mutation rewiring degron network | 0.1389 |
p.A226V | SIDM00403 | T-Lymphoblastic Leukemia | GDSC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.3056 |
p.A226V | SIDM00403 | T-Lymphoblastic Leukemia | GDSC | PPPY | ITCH | 233:236 | Mutation rewiring degron network | 0.1389 |
p.A226V | ACH-000636 | Leukemia | CCLE | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.3056 |
p.A226V | ACH-000636 | Leukemia | CCLE | PPPY | ITCH | 233:236 | Mutation rewiring degron network | 0.1389 |
p.A226V | RPMI-8402 | haematopoietic and lymphoid tissue | COSMIC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.3056 |
p.A226V | RPMI-8402 | haematopoietic and lymphoid tissue | COSMIC | PPPY | ITCH | 233:236 | Mutation rewiring degron network | 0.1389 |
p.T609A | TCGA-FE-A22Z | THCA | TCGA | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation blocking phosphorylation signal | 0.5556 |
p.S360F | TCGA-FR-A726 | SKCM | TCGA | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation altering degron motif | 0.7982 |
p.S595L | TCGA-FS-A1ZB | SKCM | TCGA | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation altering degron motif | 0.6556 |
p.S792F | TCGA-FS-A4F0 | SKCM | TCGA | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation rewiring degron network | 0.3056 |
p.S792F | TCGA-FS-A4F0 | SKCM | TCGA | PLSSS | DEG_SPOP_SBC_1 | 780:784 | Mutation rewiring degron network | 0.1111 |
p.G318W | TCGA-GN-A262 | SKCM | TCGA | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.1667 |
p.S724L | TCGA-GN-A266 | SKCM | TCGA | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.25 |
p.S724L | TCGA-GN-A266 | SKCM | TCGA | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation rewiring degron network | 0.1111 |
p.S559F | TCGA-IH-A3EA | SKCM | TCGA | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.0833 |
p.R207Q | TCGA-QN-A5NN | UCS | TCGA | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.1944 |
p.P587S | TCGA-QQ-A5VD | SARC | TCGA | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation rewiring degron network | 0.1389 |
p.R387G | TCGA-S5-A6DX | BLCA | TCGA | PTPGPT | DEG_SCF_FBW7_1 | 380:385 | Mutation rewiring degron network | 0.2778 |
p.L365Q | TCGA-W3-AA1V | SKCM | TCGA | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation rewiring degron network | 0.2222 |
p.P560L | TCGA-W3-AA1W | SKCM | TCGA | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.0556 |
p.P521L | TCGA-YS-A95C | MESO | TCGA | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.25 |
p.R365G | DO51903 | BLCA | ICGC | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation rewiring degron network | 0.2222 |
p.G409R | DO225143 | BRCA | ICGC | PFSTS | DEG_SPOP_SBC_1 | 407:411 | Mutation altering degron motif | 0.7568 |
p.P594S | DO3025 | BRCA | ICGC | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation altering degron motif | 0.6752 |
p.A542T | DO51634 | CESC | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.2222 |
p.S730C | DO49983 | CESC | ICGC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation altering degron motif | 0.7541 |
p.I207T | DO6353 | CLLE | ICGC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.1944 |
p.I233M | DO7962 | COAD | ICGC | PPPY | ITCH | 233:236 | Mutation altering degron motif | 0.7618 |
p.T425A | DO7780 | COAD | ICGC | AASTS | DEG_SPOP_SBC_1 | 414:418 | Mutation rewiring degron network | 0.1389 |
p.S330N | DO8463 | COAD | ICGC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation altering degron motif | 0.7069 |
p.T317A | DO227802 | COCA | ICGC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.1389 |
p.V549A | DO229010 | COCA | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation altering degron motif | 0.6936 |
p.V549A | DO229013 | COCA | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation altering degron motif | 0.6936 |
p.V549A | DO229016 | COCA | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation altering degron motif | 0.6936 |
p.V549A | DO229505 | LAML | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation altering degron motif | 0.6936 |
p.V549A | DO230659 | LAML | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation altering degron motif | 0.6936 |
p.V549A | DO231140 | LAML | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation altering degron motif | 0.6936 |
p.V549A | DO52365 | LUSC | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation altering degron motif | 0.6936 |
p.V549A | DO231149 | LUSC | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation altering degron motif | 0.6936 |
p.L781V | DO50440 | ESAD | ICGC | PLSSS | DEG_SPOP_SBC_1 | 780:784 | Mutation altering degron motif | 0.5654 |
p.T722M | DO50387 | ESAD | ICGC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.1944 |
p.T722M | DO50387 | ESAD | ICGC | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation rewiring degron network | 0.0556 |
p.G609V | DO234213 | ESAD | ICGC | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation blocking phosphorylation signal | 0.5556 |
p.H608R | DO234389 | ESAD | ICGC | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation substituting flanking lysine | 0.25 |
p.D225N | DO233720 | GACA | ICGC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation altering degron motif | 0.6932 |
p.S591I | DO14622 | HNSC | ICGC | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation rewiring degron network | 0.25 |
p.A637S | DO20875 | KIRP | ICGC | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.1944 |
p.T722K | DO228948 | LICA | ICGC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.1944 |
p.T722K | DO228948 | LICA | ICGC | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation rewiring degron network | 0.0556 |
p.T722K | DO228976 | LICA | ICGC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.1944 |
p.T722K | DO228976 | LICA | ICGC | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation rewiring degron network | 0.0556 |
p.P734Q | DO229018 | LICA | ICGC | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation altering degron motif | 0.7035 |
p.A596D | DO229018 | LICA | ICGC | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation altering degron motif | 0.7793 |
p.P210T | DO229022 | LICA | ICGC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.2778 |
p.P209Q | DO229027 | LICA | ICGC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.25 |
p.T792K | DO229034 | LICA | ICGC | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation rewiring degron network | 0.3056 |
p.T792K | DO229034 | LICA | ICGC | PLSSS | DEG_SPOP_SBC_1 | 780:784 | Mutation rewiring degron network | 0.1111 |
p.N423K | DO229034 | LICA | ICGC | AASTS | DEG_SPOP_SBC_1 | 414:418 | Mutation rewiring degron network | 0.1944 |
p.T332N | DO229034 | LICA | ICGC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.2778 |
p.H602N | DO229036 | LICA | ICGC | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation rewiring degron network | 0.3056 |
p.Y214C | DO44806 | LICA | ICGC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation altering degron motif | 0.7087 |
p.N271S | DO49709 | LIHC | ICGC | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation rewiring degron network | 0.2222 |
p.S591N | DO44919 | LIHC | ICGC | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation rewiring degron network | 0.25 |
p.A733E | DO48672 | LIRI | ICGC | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation altering degron motif | 0.659 |
p.P211S | DO24200 | LUAD | ICGC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.3056 |
p.S645N | DO23690 | LUAD | ICGC | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation altering degron motif | 0.7069 |
p.G518V | DO24920 | LUAD | ICGC | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.1667 |
p.V551D | DO26445 | LUSC | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.3056 |
p.A723S | DO27381 | LUSC | ICGC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.2222 |
p.A723S | DO27381 | LUSC | ICGC | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation rewiring degron network | 0.0833 |
p.P741S | DO222702 | MELA | ICGC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.0556 |
p.P741S | DO222702 | MELA | ICGC | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation rewiring degron network | 0.1944 |
p.T529I | DO222708 | MELA | ICGC | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation altering degron motif | 0.7078 |
p.S230L | DO222837 | MELA | ICGC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.1944 |
p.S230L | DO222837 | MELA | ICGC | PPPY | ITCH | 233:236 | Mutation rewiring degron network | 0.25 |
p.A543T | DO233294 | NACA | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.25 |
p.P775R | DO31250 | OV | ICGC | PLSSS | DEG_SPOP_SBC_1 | 780:784 | Mutation rewiring degron network | 0.1944 |
p.S645G | DO31230 | OV | ICGC | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation altering degron motif | 0.6993 |
p.S655Y | DO46657 | PAAD | ICGC | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.0833 |
p.A795V | DO52161 | PAEN | ICGC | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation altering degron motif | 0.6936 |
p.A278T | DO232761 | PBCA | ICGC | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation altering degron motif | 0.7139 |
p.P337S | DO229446 | SKCA | ICGC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.1389 |
p.P337S | KYSE-140 | oesophagus | COSMIC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.1389 |
p.S239F | DO229467 | SKCA | ICGC | PPPY | ITCH | 233:236 | Mutation rewiring degron network | 0.25 |
p.S537F | DO37667 | SKCM | ICGC | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.1389 |
p.S537F | DO37667 | SKCM | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.0833 |
p.K268N | DO37619 | SKCM | ICGC | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation rewiring degron network | 0.1389 |
p.P653S | DO37515 | SKCM | ICGC | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.1389 |
p.P653S | K2 | skin | COSMIC | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.1389 |
p.S770F | DO37891 | SKCM | ICGC | PLSSS | DEG_SPOP_SBC_1 | 780:784 | Mutation rewiring degron network | 0.0556 |
p.P416Q | DO37410 | SKCM | ICGC | AASTS | DEG_SPOP_SBC_1 | 414:418 | Mutation altering degron motif | 0.7035 |
p.S338F | DO48665 | SKCM | ICGC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.1111 |
p.G348C | DO47374 | SKCM | ICGC | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation rewiring degron network | 0.2222 |
p.G348C | DO41235 | UCEC | ICGC | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation rewiring degron network | 0.2222 |
p.L343Q | DO51276 | SKCM | ICGC | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation rewiring degron network | 0.0833 |
p.P538L | DO51277 | SKCM | ICGC | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.1111 |
p.P538L | DO51277 | SKCM | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.1111 |
p.A794T | DO51761 | STAD | ICGC | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation altering degron motif | 0.7139 |
p.T587A | DO39847 | THCA | ICGC | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation rewiring degron network | 0.1389 |
p.L291P | DO42033 | UCEC | ICGC | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation rewiring degron network | 0.0556 |
p.A789V | DO42312 | UCEC | ICGC | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation rewiring degron network | 0.2222 |
p.A789V | DO42312 | UCEC | ICGC | PLSSS | DEG_SPOP_SBC_1 | 780:784 | Mutation rewiring degron network | 0.1944 |
p.L515M | DO42312 | UCEC | ICGC | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.0833 |
p.P785L | DO43530 | UCEC | ICGC | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation rewiring degron network | 0.1111 |
p.P785L | DO43530 | UCEC | ICGC | PLSSS | DEG_SPOP_SBC_1 | 780:784 | Mutation rewiring degron network | 0.3056 |
p.G609D | DO42280 | UCEC | ICGC | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation blocking phosphorylation signal | 0.5556 |
p.A540V | DO223286 | UCEC | ICGC | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.0556 |
p.A540V | DO223286 | UCEC | ICGC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.1667 |
p.S227L | DO41644 | UCEC | ICGC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.2778 |
p.S227L | DO41644 | UCEC | ICGC | PPPY | ITCH | 233:236 | Mutation rewiring degron network | 0.1667 |
p.S227L | DO43755 | UCEC | ICGC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.2778 |
p.S227L | DO43755 | UCEC | ICGC | PPPY | ITCH | 233:236 | Mutation rewiring degron network | 0.1667 |
p.S227L | HT-115 | large intestine | COSMIC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.2778 |
p.S227L | HT-115 | large intestine | COSMIC | PPPY | ITCH | 233:236 | Mutation rewiring degron network | 0.1667 |
p.G518D | DO41871 | UCEC | ICGC | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.1667 |
p.P653L | DO41235 | UCEC | ICGC | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.1389 |
p.A204V | DO43755 | UCEC | ICGC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.1111 |
p.A204V | RPMI-8402 | haematopoietic and lymphoid tissue | COSMIC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.1111 |
p.A377T | SIDM00321 | Ovarian Carcinoma | GDSC | PTPGPT | DEG_SCF_FBW7_1 | 380:385 | Mutation rewiring degron network | 0.25 |
p.A377T | SIDM01154 | T-Lymphoblastic Leukemia | GDSC | PTPGPT | DEG_SCF_FBW7_1 | 380:385 | Mutation rewiring degron network | 0.25 |
p.A377T | TYK-nu | ovary | COSMIC | PTPGPT | DEG_SCF_FBW7_1 | 380:385 | Mutation rewiring degron network | 0.25 |
p.A377T | SUP-T1 | haematopoietic and lymphoid tissue | COSMIC | PTPGPT | DEG_SCF_FBW7_1 | 380:385 | Mutation rewiring degron network | 0.25 |
p.A802G | SIDM00946 | T-Lymphoblastic Leukemia | GDSC | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation rewiring degron network | 0.2778 |
p.A802G | ACH-000981 | Leukemia | CCLE | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation rewiring degron network | 0.2778 |
p.A802G | DND-41 | haematopoietic and lymphoid tissue | COSMIC | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation rewiring degron network | 0.2778 |
p.T728I | SIDM00746 | Non-Small Cell Lung Carcinoma | GDSC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation altering degron motif | 0.5966 |
p.T728I | SIDM00114 | Non-Small Cell Lung Carcinoma | GDSC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation altering degron motif | 0.5966 |
p.T728I | SIDM00907 | Burkitt's Lymphoma | GDSC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation altering degron motif | 0.5966 |
p.T728I | SIDM00138 | Non-Small Cell Lung Carcinoma | GDSC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation altering degron motif | 0.5966 |
p.L721V | SIDM00746 | Non-Small Cell Lung Carcinoma | GDSC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.1667 |
p.L721V | ACH-000766 | Lung Cancer | CCLE | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.1667 |
p.L721V | NCI-H1648 | lung | COSMIC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation rewiring degron network | 0.1667 |
p.S321F | SIDM00529 | Breast Carcinoma | GDSC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.25 |
p.S321F | ACH-000621 | Breast Cancer | CCLE | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.25 |
p.S321F | MDA-MB-157 | breast | COSMIC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.25 |
p.S321A | SIDM00529 | Breast Carcinoma | GDSC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.25 |
p.S321A | ACH-000621 | Breast Cancer | CCLE | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.25 |
p.S321A | MDA-MB-157 | breast | COSMIC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation rewiring degron network | 0.25 |
p.P359S | SIDM01032 | Esophageal Squamous Cell Carcinoma | GDSC | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation altering degron motif | 0.6752 |
p.P359S | ACH-000823 | Esophageal Cancer | CCLE | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation altering degron motif | 0.6752 |
p.P359S | KYSE-140 | oesophagus | COSMIC | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation altering degron motif | 0.6752 |
p.H325R | SIDM00596 | Endometrial Carcinoma | GDSC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation altering degron motif | 0.7133 |
p.H325R | ACH-001517 | Endometrial/Uterine Cancer | CCLE | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation altering degron motif | 0.7133 |
p.H325R | HEC-1 | endometrium | COSMIC | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation altering degron motif | 0.7133 |
p.P556H | SIDM00014 | Colorectal Carcinoma | GDSC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.1667 |
p.P556H | LIM1215 | large intestine | COSMIC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.1667 |
p.A727G | SIDM00114 | Non-Small Cell Lung Carcinoma | GDSC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation altering degron motif | 0.754 |
p.A727G | H513 | pleura | COSMIC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation altering degron motif | 0.754 |
p.G640A | SIDM00121 | T-Lymphoblastic Leukemia | GDSC | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.2778 |
p.G640A | ACH-001738 | Leukemia | CCLE | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.2778 |
p.G640A | CCRF-CEM | haematopoietic and lymphoid tissue | COSMIC | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.2778 |
p.L406P | SIDM00502 | B-Lymphoblastic Leukemia | GDSC | PFSTS | DEG_SPOP_SBC_1 | 407:411 | Mutation rewiring degron network | 0.3056 |
p.L406P | SIDM00502 | B-Lymphoblastic Leukemia | GDSC | AASTS | DEG_SPOP_SBC_1 | 414:418 | Mutation rewiring degron network | 0.1111 |
p.L406P | ACH-000157 | Lymphoma | CCLE | PFSTS | DEG_SPOP_SBC_1 | 407:411 | Mutation rewiring degron network | 0.3056 |
p.L406P | ACH-000157 | Lymphoma | CCLE | AASTS | DEG_SPOP_SBC_1 | 414:418 | Mutation rewiring degron network | 0.1111 |
p.L406P | A4-Fuk | haematopoietic and lymphoid tissue | COSMIC | PFSTS | DEG_SPOP_SBC_1 | 407:411 | Mutation rewiring degron network | 0.3056 |
p.L406P | A4-Fuk | haematopoietic and lymphoid tissue | COSMIC | AASTS | DEG_SPOP_SBC_1 | 414:418 | Mutation rewiring degron network | 0.1111 |
p.P204R | SIDM01042 | Breast Carcinoma | GDSC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.1111 |
p.P204R | ACH-001065 | Breast Cancer | CCLE | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.1111 |
p.P204R | EVSA-T | breast | COSMIC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.1111 |
p.S276L | SIDM00039 | Ovarian Carcinoma | GDSC | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation altering degron motif | 0.6556 |
p.P384A | SIDM00167 | Head and Neck Carcinoma | GDSC | PTPGPT | DEG_SCF_FBW7_1 | 380:385 | Mutation altering degron motif | 0.6392 |
p.P384A | ACH-000715 | Head and Neck Cancer | CCLE | PTPGPT | DEG_SCF_FBW7_1 | 380:385 | Mutation altering degron motif | 0.6392 |
p.T211A | SIDM01435 | Hepatocellular Carcinoma | GDSC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation rewiring degron network | 0.3056 |
p.T728P | ACH-000470 | Colon/Colorectal Cancer | CCLE | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation altering degron motif | 0.5919 |
p.T728P | SW1463 | large intestine | COSMIC | ATSST | DEG_SPOP_SBC_1 | 727:731 | Mutation altering degron motif | 0.5919 |
p.T638I | ACH-001097 | Lymphoma | CCLE | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.2222 |
p.V324I | ACH-001554 | Eye Cancer | CCLE | VHTPQPS | DEG_SCF_FBW7_1 | 324:330 | Mutation altering degron motif | 0.5965 |
p.S265N | ACH-001664 | Gastric Cancer | CCLE | PSTPAAT | DEG_SCF_FBW7_1 | 275:281 | Mutation rewiring degron network | 0.0556 |
p.A732V | ACH-001804 | Liposarcoma | CCLE | AATST | DEG_SPOP_SBC_1 | 732:736 | Mutation altering degron motif | 0.5825 |
p.T243A | ACH-001863 | Bile Duct Cancer | CCLE | PPPY | ITCH | 233:236 | Mutation rewiring degron network | 0.1389 |
p.P407S | ACH-002509 | Skin Cancer | CCLE | PFSTS | DEG_SPOP_SBC_1 | 407:411 | Mutation altering degron motif | 0.6752 |
p.L654R | SiHa | cervix | COSMIC | AYTST | DEG_SPOP_SBC_1 | 642:646 | Mutation rewiring degron network | 0.1111 |
p.L384P | A4-Fuk | haematopoietic and lymphoid tissue | COSMIC | PTPGPT | DEG_SCF_FBW7_1 | 380:385 | Mutation altering degron motif | 0.7582 |
p.D225G | A172 | central nervous system | COSMIC | IAPSAYNNAGLVPL | DEG_ODPH_VHL_1 | 212:225 | Mutation altering degron motif | 0.7198 |
p.P534H | LIM1215 | large intestine | COSMIC | IPTPQRT | DEG_SCF_FBW7_1 | 524:530 | Mutation rewiring degron network | 0.2222 |
p.A355T | SUP-T1 | haematopoietic and lymphoid tissue | COSMIC | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation altering degron motif | 0.7139 |
p.A355T | TYK-nu | ovary | COSMIC | STTTTPVPSI | DEG_COP1_1 | 352:361 | Mutation altering degron motif | 0.7139 |
p.H608Y | CHSA8926 | bone | COSMIC | ISSTPAAT | DEG_SCF_FBW7_1 | 594:601 | Mutation substituting flanking lysine | 0.25 |
p.T792A | NCI-H1105 | lung | COSMIC | VSNTPSVT | DEG_SCF_FBW7_1 | 793:800 | Mutation rewiring degron network | 0.3056 |
p.T792A | NCI-H1105 | lung | COSMIC | PLSSS | DEG_SPOP_SBC_1 | 780:784 | Mutation rewiring degron network | 0.1111 |
p.S555F | MCC13 | skin | COSMIC | ANSTS | DEG_SPOP_SBC_1 | 546:550 | Mutation rewiring degron network | 0.1944 |
p.A780G | DND-41 | haematopoietic and lymphoid tissue | COSMIC | PLSSS | DEG_SPOP_SBC_1 | 780:784 | Mutation altering degron motif | 0.754 |