DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_SPOP_SBC_1

Location: 407:411

E3 ligase: SPOP

DEGRON score: 0.9818

ASA_SCORE: 84.86

COIL: 0.9418

CONS_SCORE: 0.4907

DSS_SCORE: 0.4214

HELIX: 0.0216

FCONS_SCORE: 1.0613

RIG_SCORE: 0.6726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G409R	DO225143	BRCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.7568
p.L406P	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PFSTS	DEG_SPOP_SBC_1	0.3056
p.L406P	ACH-000157	Lymphoma	CCLE	PFSTS	DEG_SPOP_SBC_1	0.3056
p.L406P	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	PFSTS	DEG_SPOP_SBC_1	0.3056
p.P407S	ACH-002509	Skin Cancer	CCLE	PFSTS	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1449:1453	PFSTS	SPOP	0.7823	More...
Q8N3R3	T-cell activation inhibitor, mitochondrial	DEG_SPOP_SBC_1	102:106	PFSTS	SPOP	0.5848	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	407:411	PFSTS	SPOP	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons