DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SPOP_SBC_1

Location: 1449:1453

E3 ligase: SPOP

DEGRON score: 0.7823

ASA_SCORE: 95.58

COIL: 0.8044

CONS_SCORE: 0.3437

DSS_SCORE: 0.5535

HELIX: 0.0176

FCONS_SCORE: 1.2899

RIG_SCORE: 0.6878

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1449H	TCGA-AX-A1CE	UCEC	TCGA	PFSTS	DEG_SPOP_SBC_1	0.7694
p.P1449H	DO42280	UCEC	ICGC	PFSTS	DEG_SPOP_SBC_1	0.7694
p.V1447I	DO222585	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.2778
p.V1447I	DO222840	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.2778
p.E1440Q	DO222800	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.0833
p.E1440Q	DO222846	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.0833
p.E1440Q	DO229010	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.0833
p.E1440Q	DO229013	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.0833
p.E1440Q	DO229016	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.0833
p.E1440Q	DO229003	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.0833
p.E1440Q	DO229005	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.0833
p.E1440Q	DO52670	MALY	ICGC	PFSTS	DEG_SPOP_SBC_1	0.0833
p.T1461I	DO222816	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.1111
p.P1449S	DO229013	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.6752
p.P1449S	DO229016	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.6752
p.P1449S	DO229003	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.6752
p.P1449S	DO229005	COCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.6752
p.P1449S	DO51019	LAML	ICGC	PFSTS	DEG_SPOP_SBC_1	0.6752
p.P1449S	DO52373	LUSC	ICGC	PFSTS	DEG_SPOP_SBC_1	0.6752
p.P1449S	DO52363	LUSC	ICGC	PFSTS	DEG_SPOP_SBC_1	0.6752
p.P1449S	DO52355	LUSC	ICGC	PFSTS	DEG_SPOP_SBC_1	0.6752
p.E1440D	DO52670	MALY	ICGC	PFSTS	DEG_SPOP_SBC_1	0.0833
p.S1458R	SIDM01965	Esophageal Carcinoma	GDSC	PFSTS	DEG_SPOP_SBC_1	0.1944
p.V1447A	SIDM00611	Kidney Carcinoma	GDSC	PFSTS	DEG_SPOP_SBC_1	0.2778
p.V1447A	SIDM00465	Ovarian Carcinoma	GDSC	PFSTS	DEG_SPOP_SBC_1	0.2778
p.V1447A	SIDM00457	Plasma Cell Myeloma	GDSC	PFSTS	DEG_SPOP_SBC_1	0.2778
p.V1447A	ACH-000024	Myeloma	CCLE	PFSTS	DEG_SPOP_SBC_1	0.2778
p.V1447A	ACH-000684	Kidney Cancer	CCLE	PFSTS	DEG_SPOP_SBC_1	0.2778
p.V1447A	ACH-002183	Ovarian Cancer	CCLE	PFSTS	DEG_SPOP_SBC_1	0.2778
p.V1447A	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PFSTS	DEG_SPOP_SBC_1	0.2778
p.V1447A	KMRC-1	kidney	COSMIC	PFSTS	DEG_SPOP_SBC_1	0.2778
p.V1447A	OVMIU	ovary	COSMIC	PFSTS	DEG_SPOP_SBC_1	0.2778
p.S1451Y	SIDM00151	Ovarian Carcinoma	GDSC	PFSTS	DEG_SPOP_SBC_1	0.712
p.S1451Y	IGROV-1	ovary	COSMIC	PFSTS	DEG_SPOP_SBC_1	0.712
p.L1443F	SIDM00254	Neuroblastoma	GDSC	PFSTS	DEG_SPOP_SBC_1	0.1667
p.L1443F	ACH-002283	Neuroblastoma	CCLE	PFSTS	DEG_SPOP_SBC_1	0.1667
p.L1443F	NB5	autonomic_ganglia	COSMIC	PFSTS	DEG_SPOP_SBC_1	0.1667
p.P1449R	CAMA-1	breast	COSMIC	PFSTS	DEG_SPOP_SBC_1	0.7512
p.S1458C	T98G	central_nervous_system	COSMIC	PFSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1449:1453	PFSTS	SPOP	0.7823	More...
Q8N3R3	T-cell activation inhibitor, mitochondrial	DEG_SPOP_SBC_1	102:106	PFSTS	SPOP	0.5848	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	407:411	PFSTS	SPOP	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFSTS

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of PFSTS