DegronMD

Uniprot ID: Q8N3R3

Source protein: T-cell activation inhibitor, mitochondrial

Source gene: TCAIM

Class: DEG_SPOP_SBC_1

Location: 102:106

E3 ligase: SPOP

DEGRON score: 0.5848

ASA_SCORE: 72.12

COIL: 0.7786

CONS_SCORE: 0.303

DSS_SCORE: 0.36

HELIX: 0.0744

FCONS_SCORE: 0.6327

RIG_SCORE: 0.7127

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P102H	TCGA-AP-A051	UCEC	TCGA	PFSTS	DEG_SPOP_SBC_1	0.7694
p.P102H	DO42673	UCEC	ICGC	PFSTS	DEG_SPOP_SBC_1	0.7694
p.D98Y	TCGA-DX-A6BA	SARC	TCGA	PFSTS	DEG_SPOP_SBC_1	0.2222
p.D98Y	DO219995	SARC	ICGC	PFSTS	DEG_SPOP_SBC_1	0.2222
p.S96F	TCGA-FW-A3R5	SKCM	TCGA	PFSTS	DEG_SPOP_SBC_1	0.1667
p.S96F	DO37406	SKCM	ICGC	PFSTS	DEG_SPOP_SBC_1	0.1667
p.G107A	TCGA-L5-A8NI	ESCA	TCGA	PFSTS	DEG_SPOP_SBC_1	0.3056
p.S96C	TCGA-XF-AAN5	BLCA	TCGA	PFSTS	DEG_SPOP_SBC_1	0.1667
p.S96C	DO51945	BLCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.1667
p.T105A	DO228246	BRCA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.7139
p.G99V	DO229006	LICA	ICGC	PFSTS	DEG_SPOP_SBC_1	0.25
p.P102T	DO50834	LIRI	ICGC	PFSTS	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1449:1453	PFSTS	SPOP	0.7823	More...
Q8N3R3	T-cell activation inhibitor, mitochondrial	DEG_SPOP_SBC_1	102:106	PFSTS	SPOP	0.5848	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	407:411	PFSTS	SPOP	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons