DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_SCF_FBW7_1

Location: 275:281

E3 ligase: FBXW7

DEGRON score: 0.9966

ASA_SCORE: 82.6429

COIL: 0.9631

CONS_SCORE: 0.5408

DSS_SCORE: 0.6542

HELIX: 0.0111

FCONS_SCORE: 1.1411

RIG_SCORE: 0.5641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P270A	TCGA-CR-6481	HNSC	TCGA	PSTPAAT	DEG_SCF_FBW7_1	0.1944
p.K290N	TCGA-D3-A2JK	SKCM	TCGA	PSTPAAT	DEG_SCF_FBW7_1	0.1944
p.P275H	TCGA-D9-A149	SKCM	TCGA	PSTPAAT	DEG_SCF_FBW7_1	0.7694
p.S269P	TCGA-EB-A51B	SKCM	TCGA	PSTPAAT	DEG_SCF_FBW7_1	0.1667
p.H271N	TCGA-EE-A20F	SKCM	TCGA	PSTPAAT	DEG_SCF_FBW7_1	0.2222
p.P270S	TCGA-EE-A29D	SKCM	TCGA	PSTPAAT	DEG_SCF_FBW7_1	0.1944
p.P284S	TCGA-EE-A2MR	SKCM	TCGA	PSTPAAT	DEG_SCF_FBW7_1	0.25
p.N271S	DO49709	LIHC	ICGC	PSTPAAT	DEG_SCF_FBW7_1	0.2222
p.A278T	DO232761	PBCA	ICGC	PSTPAAT	DEG_SCF_FBW7_1	0.7139
p.K268N	DO37619	SKCM	ICGC	PSTPAAT	DEG_SCF_FBW7_1	0.1389
p.L291P	DO42033	UCEC	ICGC	PSTPAAT	DEG_SCF_FBW7_1	0.0556
p.S276L	SIDM00039	Ovarian Carcinoma	GDSC	PSTPAAT	DEG_SCF_FBW7_1	0.6556
p.S265N	ACH-001664	Gastric Cancer	CCLE	PSTPAAT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XN7	Proline and serine-rich protein 1	DEG_SCF_FBW7_1	275:281	PSTPAAT	FBXW7	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons