DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_SCF_FBW7_1

Location: 594:601

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 76.0875

COIL: 0.9466

CONS_SCORE: 0.3636

DSS_SCORE: 0.5683

HELIX: 0.0185

FCONS_SCORE: 0.8885

RIG_SCORE: 0.6795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H593Y	TCGA-B5-A3FA	UCEC	TCGA	ISSTPAAT	DEG_SCF_FBW7_1	0.3056
p.G588S	TCGA-EE-A2MI	SKCM	TCGA	ISSTPAAT	DEG_SCF_FBW7_1	0.1667
p.T609A	TCGA-FE-A22Z	THCA	TCGA	ISSTPAAT	DEG_SCF_FBW7_1	0.5556
p.S595L	TCGA-FS-A1ZB	SKCM	TCGA	ISSTPAAT	DEG_SCF_FBW7_1	0.6556
p.P587S	TCGA-QQ-A5VD	SARC	TCGA	ISSTPAAT	DEG_SCF_FBW7_1	0.1389
p.P594S	DO3025	BRCA	ICGC	ISSTPAAT	DEG_SCF_FBW7_1	0.6752
p.G609V	DO234213	ESAD	ICGC	ISSTPAAT	DEG_SCF_FBW7_1	0.5556
p.H608R	DO234389	ESAD	ICGC	ISSTPAAT	DEG_SCF_FBW7_1	0.25
p.S591I	DO14622	HNSC	ICGC	ISSTPAAT	DEG_SCF_FBW7_1	0.25
p.A596D	DO229018	LICA	ICGC	ISSTPAAT	DEG_SCF_FBW7_1	0.7793
p.H602N	DO229036	LICA	ICGC	ISSTPAAT	DEG_SCF_FBW7_1	0.3056
p.S591N	DO44919	LIHC	ICGC	ISSTPAAT	DEG_SCF_FBW7_1	0.25
p.T587A	DO39847	THCA	ICGC	ISSTPAAT	DEG_SCF_FBW7_1	0.1389
p.G609D	DO42280	UCEC	ICGC	ISSTPAAT	DEG_SCF_FBW7_1	0.5556
p.H608Y	CHSA8926	bone	COSMIC	ISSTPAAT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XN7	Proline and serine-rich protein 1	DEG_SCF_FBW7_1	594:601	ISSTPAAT	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons