DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_SCF_FBW7_1

Location: 380:385

E3 ligase: FBXW7

DEGRON score: 0.9916

ASA_SCORE: 84.0833

COIL: 0.977

CONS_SCORE: 0.467

DSS_SCORE: 0.721

HELIX: 0.0073

FCONS_SCORE: 1.1208

RIG_SCORE: 0.5823

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G370C	TCGA-A5-A0G2	UCEC	TCGA	PTPGPT	DEG_SCF_FBW7_1	0.0556
p.G370C	TCGA-BF-A1Q0	SKCM	TCGA	PTPGPT	DEG_SCF_FBW7_1	0.0556
p.R387G	TCGA-S5-A6DX	BLCA	TCGA	PTPGPT	DEG_SCF_FBW7_1	0.2778
p.A377T	SIDM00321	Ovarian Carcinoma	GDSC	PTPGPT	DEG_SCF_FBW7_1	0.25
p.A377T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PTPGPT	DEG_SCF_FBW7_1	0.25
p.A377T	TYK-nu	ovary	COSMIC	PTPGPT	DEG_SCF_FBW7_1	0.25
p.A377T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGPT	DEG_SCF_FBW7_1	0.25
p.P384A	SIDM00167	Head and Neck Carcinoma	GDSC	PTPGPT	DEG_SCF_FBW7_1	0.6392
p.P384A	ACH-000715	Head and Neck Cancer	CCLE	PTPGPT	DEG_SCF_FBW7_1	0.6392
p.L384P	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGPT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
I3L273	Golgi-associated olfactory signaling regulator	DEG_SCF_FBW7_1	137:142	PTPGPT	FBXW7	0.9799	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SCF_FBW7_1	380:385	PTPGPT	FBXW7	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons