DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPGPT
Uniprot ID:
I3L273
Source protein:
Golgi-associated olfactory signaling regulator
Source gene:
GFY
Class:
DEG_SCF_FBW7_1
Location:
137:142
E3 ligase:
FBXW7
DEGRON score:
0.9799
ASA_SCORE:
80.5
COIL:
0.9713
CONS_SCORE:
0
DSS_SCORE:
0.8725
HELIX:
0.0103
FCONS_SCORE:
0
RIG_SCORE:
0.4482
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GFY mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPGPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
I3L273
Golgi-associated olfactory signaling regulator
DEG_SCF_FBW7_1
137:142
PTPGPT
FBXW7
0.9799
More...
Q86XN7
Proline and serine-rich protein 1
DEG_SCF_FBW7_1
380:385
PTPGPT
FBXW7
0.9916
More...