DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_SCF_FBW7_1

Location: 324:330

E3 ligase: FBXW7

DEGRON score: 0.8922

ASA_SCORE: 95.1571

COIL: 0.965

CONS_SCORE: 0.5308

DSS_SCORE: 0.5088

HELIX: 0.01

FCONS_SCORE: 1.0049

RIG_SCORE: 0.6659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T326I	TCGA-DI-A1BU	UCEC	TCGA	VHTPQPS	DEG_SCF_FBW7_1	0.7078
p.G318W	TCGA-GN-A262	SKCM	TCGA	VHTPQPS	DEG_SCF_FBW7_1	0.1667
p.S330N	DO8463	COAD	ICGC	VHTPQPS	DEG_SCF_FBW7_1	0.7069
p.T317A	DO227802	COCA	ICGC	VHTPQPS	DEG_SCF_FBW7_1	0.1389
p.T332N	DO229034	LICA	ICGC	VHTPQPS	DEG_SCF_FBW7_1	0.2778
p.P337S	DO229446	SKCA	ICGC	VHTPQPS	DEG_SCF_FBW7_1	0.1389
p.P337S	KYSE-140	oesophagus	COSMIC	VHTPQPS	DEG_SCF_FBW7_1	0.1389
p.S338F	DO48665	SKCM	ICGC	VHTPQPS	DEG_SCF_FBW7_1	0.1111
p.S321F	SIDM00529	Breast Carcinoma	GDSC	VHTPQPS	DEG_SCF_FBW7_1	0.25
p.S321F	ACH-000621	Breast Cancer	CCLE	VHTPQPS	DEG_SCF_FBW7_1	0.25
p.S321F	MDA-MB-157	breast	COSMIC	VHTPQPS	DEG_SCF_FBW7_1	0.25
p.S321A	SIDM00529	Breast Carcinoma	GDSC	VHTPQPS	DEG_SCF_FBW7_1	0.25
p.S321A	ACH-000621	Breast Cancer	CCLE	VHTPQPS	DEG_SCF_FBW7_1	0.25
p.S321A	MDA-MB-157	breast	COSMIC	VHTPQPS	DEG_SCF_FBW7_1	0.25
p.H325R	SIDM00596	Endometrial Carcinoma	GDSC	VHTPQPS	DEG_SCF_FBW7_1	0.7133
p.H325R	ACH-001517	Endometrial/Uterine Cancer	CCLE	VHTPQPS	DEG_SCF_FBW7_1	0.7133
p.H325R	HEC-1	endometrium	COSMIC	VHTPQPS	DEG_SCF_FBW7_1	0.7133
p.V324I	ACH-001554	Eye Cancer	CCLE	VHTPQPS	DEG_SCF_FBW7_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XN7	Proline and serine-rich protein 1	DEG_SCF_FBW7_1	324:330	VHTPQPS	FBXW7	0.8922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons