DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_COP1_1

Location: 352:361

E3 ligase: COP1

DEGRON score: 0.9689

ASA_SCORE: 85.66

COIL: 0.9563

CONS_SCORE: 0.578

DSS_SCORE: 0.4775

HELIX: 0.0184

FCONS_SCORE: 1.1248

RIG_SCORE: 0.7276

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G370C	TCGA-A5-A0G2	UCEC	TCGA	STTTTPVPSI	DEG_COP1_1	0.0833
p.G370C	TCGA-BF-A1Q0	SKCM	TCGA	STTTTPVPSI	DEG_COP1_1	0.0833
p.S352N	TCGA-AD-6889	COAD	TCGA	STTTTPVPSI	DEG_COP1_1	0.7069
p.S360F	TCGA-FR-A726	SKCM	TCGA	STTTTPVPSI	DEG_COP1_1	0.7982
p.L365Q	TCGA-W3-AA1V	SKCM	TCGA	STTTTPVPSI	DEG_COP1_1	0.2222
p.R365G	DO51903	BLCA	ICGC	STTTTPVPSI	DEG_COP1_1	0.2222
p.G348C	DO47374	SKCM	ICGC	STTTTPVPSI	DEG_COP1_1	0.2222
p.G348C	DO41235	UCEC	ICGC	STTTTPVPSI	DEG_COP1_1	0.2222
p.L343Q	DO51276	SKCM	ICGC	STTTTPVPSI	DEG_COP1_1	0.0833
p.P359S	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	STTTTPVPSI	DEG_COP1_1	0.6752
p.P359S	ACH-000823	Esophageal Cancer	CCLE	STTTTPVPSI	DEG_COP1_1	0.6752
p.P359S	KYSE-140	oesophagus	COSMIC	STTTTPVPSI	DEG_COP1_1	0.6752
p.A355T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	STTTTPVPSI	DEG_COP1_1	0.7139
p.A355T	TYK-nu	ovary	COSMIC	STTTTPVPSI	DEG_COP1_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XN7	Proline and serine-rich protein 1	DEG_COP1_1	352:361	STTTTPVPSI	COP1	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons