DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_SCF_FBW7_1

Location: 793:800

E3 ligase: FBXW7

DEGRON score: 0.9577

ASA_SCORE: 86.2

COIL: 0.9453

CONS_SCORE: 0.5738

DSS_SCORE: 0.3797

HELIX: 0.0151

FCONS_SCORE: 0.8891

RIG_SCORE: 0.6581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P797R	TCGA-25-2398	OV	TCGA	VSNTPSVT	DEG_SCF_FBW7_1	0.7512
p.P807L	TCGA-AX-A06H	UCEC	TCGA	VSNTPSVT	DEG_SCF_FBW7_1	0.1389
p.S792F	TCGA-FS-A4F0	SKCM	TCGA	VSNTPSVT	DEG_SCF_FBW7_1	0.3056
p.T792K	DO229034	LICA	ICGC	VSNTPSVT	DEG_SCF_FBW7_1	0.3056
p.A795V	DO52161	PAEN	ICGC	VSNTPSVT	DEG_SCF_FBW7_1	0.6936
p.A794T	DO51761	STAD	ICGC	VSNTPSVT	DEG_SCF_FBW7_1	0.7139
p.A789V	DO42312	UCEC	ICGC	VSNTPSVT	DEG_SCF_FBW7_1	0.2222
p.P785L	DO43530	UCEC	ICGC	VSNTPSVT	DEG_SCF_FBW7_1	0.1111
p.A802G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VSNTPSVT	DEG_SCF_FBW7_1	0.2778
p.A802G	ACH-000981	Leukemia	CCLE	VSNTPSVT	DEG_SCF_FBW7_1	0.2778
p.A802G	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VSNTPSVT	DEG_SCF_FBW7_1	0.2778
p.T792A	NCI-H1105	lung	COSMIC	VSNTPSVT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XN7	Proline and serine-rich protein 1	DEG_SCF_FBW7_1	793:800	VSNTPSVT	FBXW7	0.9577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons