DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_SPOP_SBC_1

Location: 546:550

E3 ligase: SPOP

DEGRON score: 0.9669

ASA_SCORE: 82.56

COIL: 0.9492

CONS_SCORE: 0.4393

DSS_SCORE: 0.4672

HELIX: 0.0252

FCONS_SCORE: 0.9716

RIG_SCORE: 0.6477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G540V	TCGA-69-7978	LUAD	TCGA	ANSTS	DEG_SPOP_SBC_1	0.1667
p.G540D	TCGA-B5-A3FC	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.1667
p.L537M	TCGA-D1-A103	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.0833
p.S559F	TCGA-IH-A3EA	SKCM	TCGA	ANSTS	DEG_SPOP_SBC_1	0.0833
p.P560L	TCGA-W3-AA1W	SKCM	TCGA	ANSTS	DEG_SPOP_SBC_1	0.0556
p.A542T	DO51634	CESC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.2222
p.V549A	DO229010	COCA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.6936
p.V549A	DO229013	COCA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.6936
p.V549A	DO229016	COCA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.6936
p.V549A	DO229505	LAML	ICGC	ANSTS	DEG_SPOP_SBC_1	0.6936
p.V549A	DO230659	LAML	ICGC	ANSTS	DEG_SPOP_SBC_1	0.6936
p.V549A	DO231140	LAML	ICGC	ANSTS	DEG_SPOP_SBC_1	0.6936
p.V549A	DO52365	LUSC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.6936
p.V549A	DO231149	LUSC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.6936
p.V551D	DO26445	LUSC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.3056
p.A543T	DO233294	NACA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.25
p.S537F	DO37667	SKCM	ICGC	ANSTS	DEG_SPOP_SBC_1	0.0833
p.P538L	DO51277	SKCM	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1111
p.A540V	DO223286	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1667
p.P556H	SIDM00014	Colorectal Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.1667
p.P556H	LIM1215	large_intestine	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.1667
p.S555F	MCC13	skin	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0PJK1	Sodium/glucose cotransporter 5	DEG_SPOP_SBC_1	3:7	ANSTS	SPOP	0.522	More...
P22794	Protein EVI2A	DEG_SPOP_SBC_1	37:41	ANSTS	SPOP	0.9697	More...
P43121	Cell surface glycoprotein MUC18	DEG_SPOP_SBC_1	543:547	ANSTS	SPOP	0.9356	More...
Q6UXK2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	DEG_SPOP_SBC_1	363:367	ANSTS	SPOP	0.656	More...
Q9BTN0	Leucine-rich repeat and fibronectin type-III domain-containing protein 3	DEG_SPOP_SBC_1	392:396	ANSTS	SPOP	0.9888	More...
Q9UKI2	Cdc42 effector protein 3	DEG_SPOP_SBC_1	87:91	ANSTS	SPOP	0.9981	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	546:550	ANSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons