DegronMD - Q6UXK2(ISLR2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T366M	TCGA-AJ-A3EL	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.7423
p.T366M	TCGA-DU-A5TY	LGG	TCGA	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.7423
p.T366M	DO44577	LGG	ICGC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.7423
p.T366M	DO41542	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.7423
p.R508C	TCGA-AN-A0FW	BRCA	TCGA	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2778
p.R508C	DO2825	BRCA	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2778
p.R369C	TCGA-AX-A2HC	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.R369C	DO41572	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.R369C	ACH-002026	Endometrial/Uterine Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.A490V	TCGA-D3-A8GM	SKCM	TCGA	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.A490V	DO50288	SKCM	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.P534L	TCGA-DD-AACG	LIHC	TCGA	GRRPLRLLY	DEG_APCC_DBOX_1	523:531	Mutation rewiring degron network	0.25
p.P534L	DO52202	LIHC	ICGC	GRRPLRLLY	DEG_APCC_DBOX_1	523:531	Mutation rewiring degron network	0.25
p.E497K	TCGA-IB-A6UG	PAAD	TCGA	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.3056
p.E497K	DO225209	BRCA	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.3056
p.E497K	DO49414	PAAD	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.3056
p.E497K	SIDM00589	Oral Cavity Carcinoma	GDSC	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.3056
p.E497K	ACH-000778	Head and Neck Cancer	CCLE	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.3056
p.E497K	HSC-3	upper aerodigestive tract	COSMIC	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.3056
p.G537S	DO50541	BOCA	ICGC	GRRPLRLLY	DEG_APCC_DBOX_1	523:531	Mutation rewiring degron network	0.1667
p.R528C	DO220828	BRCA	ICGC	GRRPLRLLY	DEG_APCC_DBOX_1	523:531	Mutation altering degron motif	0.719
p.E495K	DO1076	BRCA	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.25
p.A494V	DO222454	BTCA	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2222
p.A494V	ACH-001719	Ovarian Cancer	CCLE	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2222
p.R356H	DO230314	COCA	ICGC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1389
p.A363T	DO227987	COCA	ICGC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.7139
p.G376W	DO229029	LICA	ICGC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.0833
p.G515R	DO229256	LMS	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.0833
p.G515R	DO229256	LMS	ICGC	GRRPLRLLY	DEG_APCC_DBOX_1	523:531	Mutation rewiring degron network	0.1111
p.A374E	DO234007	THCA	ICGC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1389
p.A535V	SIDM01307	Colorectal Carcinoma	GDSC	GRRPLRLLY	DEG_APCC_DBOX_1	523:531	Mutation rewiring degron network	0.2222
p.R369H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.R369H	SIDM00217	Colorectal Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.R369H	ACH-000795	Leukemia	CCLE	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.R369H	ACH-000999	Colon/Colorectal Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.R369H	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.R369H	SNU-1040	large intestine	COSMIC	ANSTS	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.A506T	SIDM00241	Breast Carcinoma	GDSC	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.6028
p.L527M	SIDM00118	Colorectal Carcinoma	GDSC	GRRPLRLLY	DEG_APCC_DBOX_1	523:531	Mutation altering degron motif	0.711
p.W509R	ACH-000842	Colon/Colorectal Cancer	CCLE	ARVQLTPLA	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.25
p.L532V	ACH-001412	Bladder Cancer	CCLE	GRRPLRLLY	DEG_APCC_DBOX_1	523:531	Mutation rewiring degron network	0.3056
p.Y531F	ACH-002041	Thyroid Cancer	CCLE	GRRPLRLLY	DEG_APCC_DBOX_1	523:531	Mutation altering degron motif	0.6417

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ISLR2

UniProt ID: Q6UXK2

Entrez ID: 57611

Protein name: Immunoglobulin superfamily containing leucine-rich repeat protein 2 (Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ISLR2 in