DegronMD

Uniprot ID: Q6UXK2

Source protein: Immunoglobulin superfamily containing leucine-rich repeat protein 2

Source gene: ISLR2

Class: DEG_SPOP_SBC_1

Location: 363:367

E3 ligase: SPOP

DEGRON score: 0.656

ASA_SCORE: 61.68

COIL: 0.0798

CONS_SCORE: 0.4401

DSS_SCORE: 0.3803

HELIX: 0.0032

FCONS_SCORE: 0.8071

RIG_SCORE: 0.7209

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T366M	TCGA-AJ-A3EL	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.7423
p.T366M	TCGA-DU-A5TY	LGG	TCGA	ANSTS	DEG_SPOP_SBC_1	0.7423
p.T366M	DO44577	LGG	ICGC	ANSTS	DEG_SPOP_SBC_1	0.7423
p.T366M	DO41542	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.7423
p.R369C	TCGA-AX-A2HC	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.2778
p.R369C	DO41572	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.2778
p.R369C	ACH-002026	Endometrial/Uterine Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.2778
p.R356H	DO230314	COCA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1389
p.A363T	DO227987	COCA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.7139
p.G376W	DO229029	LICA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.0833
p.A374E	DO234007	THCA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1389
p.R369H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	ANSTS	DEG_SPOP_SBC_1	0.2778
p.R369H	SIDM00217	Colorectal Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.2778
p.R369H	ACH-000795	Leukemia	CCLE	ANSTS	DEG_SPOP_SBC_1	0.2778
p.R369H	ACH-000999	Colon/Colorectal Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.2778
p.R369H	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.2778
p.R369H	SNU-1040	large_intestine	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0PJK1	Sodium/glucose cotransporter 5	DEG_SPOP_SBC_1	3:7	ANSTS	SPOP	0.522	More...
P22794	Protein EVI2A	DEG_SPOP_SBC_1	37:41	ANSTS	SPOP	0.9697	More...
P43121	Cell surface glycoprotein MUC18	DEG_SPOP_SBC_1	543:547	ANSTS	SPOP	0.9356	More...
Q6UXK2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	DEG_SPOP_SBC_1	363:367	ANSTS	SPOP	0.656	More...
Q9BTN0	Leucine-rich repeat and fibronectin type-III domain-containing protein 3	DEG_SPOP_SBC_1	392:396	ANSTS	SPOP	0.9888	More...
Q9UKI2	Cdc42 effector protein 3	DEG_SPOP_SBC_1	87:91	ANSTS	SPOP	0.9981	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	546:550	ANSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons