DegronMD

Uniprot ID: P43121

Source protein: Cell surface glycoprotein MUC18

Source gene: MCAM

Class: DEG_SPOP_SBC_1

Location: 543:547

E3 ligase: SPOP

DEGRON score: 0.9356

ASA_SCORE: 67.56

COIL: 0.8136

CONS_SCORE: 0.6835

DSS_SCORE: 0.6706

HELIX: 0.0414

FCONS_SCORE: 1.4502

RIG_SCORE: 0.654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P555S	TCGA-50-7109	LUAD	TCGA	ANSTS	DEG_SPOP_SBC_1	0.1111
p.P555S	DO24487	LUAD	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1111
p.A537T	TCGA-AJ-A3BH	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.1667
p.P539S	TCGA-B5-A11E	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.2222
p.E549D	TCGA-FS-A1ZG	SKCM	TCGA	ANSTS	DEG_SPOP_SBC_1	0.2778
p.E549D	DO37523	SKCM	ICGC	ANSTS	DEG_SPOP_SBC_1	0.2778
p.E556D	TCGA-UY-A9PD	BLCA	TCGA	ANSTS	DEG_SPOP_SBC_1	0.0833
p.E556D	DO219042	BLCA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.0833
p.T534I	SIDM01117	Small Cell Lung Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.0833
p.T534I	ACH-002176	Lung Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.0833
p.T534I	NCI-H748	lung	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.0833
p.P555R	SIDM00705	Non-Cancerous	GDSC	ANSTS	DEG_SPOP_SBC_1	0.1111
p.P555R	SIDM00696	Non-Cancerous	GDSC	ANSTS	DEG_SPOP_SBC_1	0.1111
p.P555R	SIDM00772	Breast Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.1111
p.P555R	ACH-002369	Non-Cancerous	CCLE	ANSTS	DEG_SPOP_SBC_1	0.1111
p.P555R	ACH-002383	Non-Cancerous	CCLE	ANSTS	DEG_SPOP_SBC_1	0.1111
p.T534A	ACH-000306	Non-Cancerous	CCLE	ANSTS	DEG_SPOP_SBC_1	0.0833
p.S557R	ACH-000586	Lung Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.0556
p.S557R	NCI-H1876	lung	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.0556
p.T541S	ACH-001536	Bile Duct Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0PJK1	Sodium/glucose cotransporter 5	DEG_SPOP_SBC_1	3:7	ANSTS	SPOP	0.522	More...
P22794	Protein EVI2A	DEG_SPOP_SBC_1	37:41	ANSTS	SPOP	0.9697	More...
P43121	Cell surface glycoprotein MUC18	DEG_SPOP_SBC_1	543:547	ANSTS	SPOP	0.9356	More...
Q6UXK2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	DEG_SPOP_SBC_1	363:367	ANSTS	SPOP	0.656	More...
Q9BTN0	Leucine-rich repeat and fibronectin type-III domain-containing protein 3	DEG_SPOP_SBC_1	392:396	ANSTS	SPOP	0.9888	More...
Q9UKI2	Cdc42 effector protein 3	DEG_SPOP_SBC_1	87:91	ANSTS	SPOP	0.9981	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	546:550	ANSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons