DegronMD

Uniprot ID: Q9BTN0

Source protein: Leucine-rich repeat and fibronectin type-III domain-containing protein 3

Source gene: LRFN3

Class: DEG_SPOP_SBC_1

Location: 392:396

E3 ligase: SPOP

DEGRON score: 0.9888

ASA_SCORE: 69.88

COIL: 0.862

CONS_SCORE: 0.7935

DSS_SCORE: 0.8273

HELIX: 0.0352

FCONS_SCORE: 1.1427

RIG_SCORE: 0.6016

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P388H	TCGA-A5-A1OF	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.2222
p.P388H	DO233697	GACA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.2222
p.P388H	DO42568	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.2222
p.P388L	TCGA-AB-2828	LAML	TCGA	ANSTS	DEG_SPOP_SBC_1	0.2222
p.P388L	DO21571	LAML	ICGC	ANSTS	DEG_SPOP_SBC_1	0.2222
p.N393S	TCGA-B5-A3FC	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.5958
p.N393S	DO41871	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.5958
p.R401Q	TCGA-E7-A7DU	BLCA	TCGA	ANSTS	DEG_SPOP_SBC_1	0.1944
p.R401Q	DO219016	BLCA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1944
p.R401Q	DO233898	GACA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1944
p.R401Q	SIDM00217	Colorectal Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.1944
p.R401Q	ACH-000999	Colon/Colorectal Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.1944
p.R401Q	SNU-1040	large_intestine	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.1944
p.T395I	DO23192	LINC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.7078
p.S396G	SIDM00131	Glioma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.6993
p.S396G	ACH-000329	Brain Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.6993
p.S396G	CCF-STTG1	central_nervous_system	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.6993
p.S396C	SIDM00216	Colorectal Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.7541
p.S396C	ACH-000989	Colon/Colorectal Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.7541
p.S396C	SNU-175	large_intestine	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.7541
p.P400S	SIDM00506	Small Cell Lung Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.2222
p.P400S	SIDM01325	Pancreatic Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.2222
p.P405S	SIDM00890	Melanoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.0833
p.P405S	ACH-000580	Skin Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.0833
p.P405S	C32	skin	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.0833
p.R401W	SIDM00213	Thyroid Gland Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.1944
p.R401W	ACH-000903	Thyroid Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.1944
p.R401W	FTC-133	thyroid	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0PJK1	Sodium/glucose cotransporter 5	DEG_SPOP_SBC_1	3:7	ANSTS	SPOP	0.522	More...
P22794	Protein EVI2A	DEG_SPOP_SBC_1	37:41	ANSTS	SPOP	0.9697	More...
P43121	Cell surface glycoprotein MUC18	DEG_SPOP_SBC_1	543:547	ANSTS	SPOP	0.9356	More...
Q6UXK2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	DEG_SPOP_SBC_1	363:367	ANSTS	SPOP	0.656	More...
Q9BTN0	Leucine-rich repeat and fibronectin type-III domain-containing protein 3	DEG_SPOP_SBC_1	392:396	ANSTS	SPOP	0.9888	More...
Q9UKI2	Cdc42 effector protein 3	DEG_SPOP_SBC_1	87:91	ANSTS	SPOP	0.9981	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	546:550	ANSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ANSTS

Degron related mutations and impact score

Drug responses associated with LRFN3 mutations

All proteins holding degron of ANSTS