DegronMD - Q9BTN0(LRFN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P388H	TCGA-A5-A1OF	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2222
p.P388H	DO233697	GACA	ICGC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2222
p.P388H	DO42568	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2222
p.P388L	TCGA-AB-2828	LAML	TCGA	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2222
p.P388L	DO21571	LAML	ICGC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2222
p.N393S	TCGA-B5-A3FC	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.5958
p.N393S	DO41871	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.5958
p.R401Q	TCGA-E7-A7DU	BLCA	TCGA	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1944
p.R401Q	DO219016	BLCA	ICGC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1944
p.R401Q	DO233898	GACA	ICGC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1944
p.R401Q	SIDM00217	Colorectal Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1944
p.R401Q	ACH-000999	Colon/Colorectal Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1944
p.R401Q	SNU-1040	large intestine	COSMIC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1944
p.T395I	DO23192	LINC	ICGC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.7078
p.S396G	SIDM00131	Glioma	GDSC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.6993
p.S396G	ACH-000329	Brain Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.6993
p.S396G	CCF-STTG1	central nervous system	COSMIC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.6993
p.S396C	SIDM00216	Colorectal Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.7541
p.S396C	ACH-000989	Colon/Colorectal Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.7541
p.S396C	SNU-175	large intestine	COSMIC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.7541
p.P400S	SIDM00506	Small Cell Lung Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2222
p.P400S	SIDM01325	Pancreatic Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2222
p.P405S	SIDM00890	Melanoma	GDSC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.0833
p.P405S	ACH-000580	Skin Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.0833
p.P405S	C32	skin	COSMIC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.0833
p.R401W	SIDM00213	Thyroid Gland Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1944
p.R401W	ACH-000903	Thyroid Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1944
p.R401W	FTC-133	thyroid	COSMIC	ANSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1944

Kaplan plot for LRFN3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRFN3

UniProt ID: Q9BTN0

Entrez ID: 79414

Protein name: Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRFN3 in