DegronMD

Uniprot ID: A0PJK1

Source protein: Sodium/glucose cotransporter 5

Source gene: SLC5A10

Class: DEG_SPOP_SBC_1

Location: 3:7

E3 ligase: SPOP

DEGRON score: 0.522

ASA_SCORE: 91.5

COIL: 0.9288

CONS_SCORE: 0.1994

DSS_SCORE: 0.6965

HELIX: 0.0622

FCONS_SCORE: 0.7727

RIG_SCORE: 0.6904

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3T	TCGA-AX-A2HC	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.7139
p.A3T	TCGA-DM-A1HB	COAD	TCGA	ANSTS	DEG_SPOP_SBC_1	0.7139
p.A3T	DO41572	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.7139
p.S5F	DO222542	MELA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.7982
p.T11I	SIDM00528	Breast Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.2222
p.T11I	ACH-000934	Breast Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	0.2222
p.T11I	MDA-MB-361	breast	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.2222
p.D8N	SIDM01689	B-Lymphoblastic Leukemia	GDSC	ANSTS	DEG_SPOP_SBC_1	0.3056
p.D8N	ACH-000492	Leukemia	CCLE	ANSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0PJK1	Sodium/glucose cotransporter 5	DEG_SPOP_SBC_1	3:7	ANSTS	SPOP	0.522	More...
P22794	Protein EVI2A	DEG_SPOP_SBC_1	37:41	ANSTS	SPOP	0.9697	More...
P43121	Cell surface glycoprotein MUC18	DEG_SPOP_SBC_1	543:547	ANSTS	SPOP	0.9356	More...
Q6UXK2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	DEG_SPOP_SBC_1	363:367	ANSTS	SPOP	0.656	More...
Q9BTN0	Leucine-rich repeat and fibronectin type-III domain-containing protein 3	DEG_SPOP_SBC_1	392:396	ANSTS	SPOP	0.9888	More...
Q9UKI2	Cdc42 effector protein 3	DEG_SPOP_SBC_1	87:91	ANSTS	SPOP	0.9981	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	546:550	ANSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons