DegronMD - Q9UKI2(CDC42EP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S91L	TCGA-32-2616	GBM	TCGA	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.8778
p.S91L	TCGA-D5-5541	COAD	TCGA	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.8778
p.S91L	DO10475	COAD	ICGC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.8778
p.S91L	DO13462	GBM	ICGC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.8778
p.S91L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.8778
p.S91L	H513	pleura	COSMIC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.8778
p.S93Y	TCGA-55-8205	LUAD	TCGA	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation blocking phosphorylation signal	0.7222
p.S93Y	DO48884	LUAD	ICGC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation blocking phosphorylation signal	0.7222
p.F84L	TCGA-AA-3977	COAD	TCGA	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.25
p.F84L	TCGA-B5-A3FA	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.25
p.F84L	DO8730	COAD	ICGC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.25
p.F84L	DO229045	LICA	ICGC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.25
p.F84L	DO52402	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.25
p.F78L	TCGA-EE-A185	SKCM	TCGA	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.F78L	DO222658	MELA	ICGC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.F78L	DO37599	SKCM	ICGC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.T98M	DO233693	GACA	ICGC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation blocking phosphorylation signal	0.5833
p.R86Q	DO35140	PACA	ICGC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.V94M	SIDM00845	Burkitt's Lymphoma	GDSC	ANSTS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.25

Kaplan plot for CDC42EP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC42EP3

UniProt ID: Q9UKI2

Entrez ID: 10602

Protein name: Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC42EP3 in