DegronMD

Uniprot ID: Q9UKI2

Source protein: Cdc42 effector protein 3

Source gene: CDC42EP3

Class: DEG_SPOP_SBC_1

Location: 87:91

E3 ligase: SPOP

DEGRON score: 0.9981

ASA_SCORE: 73.18

COIL: 0.904

CONS_SCORE: 0.7109

DSS_SCORE: 0.4866

HELIX: 0.0604

FCONS_SCORE: 1.0409

RIG_SCORE: 0.6839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S91L	TCGA-32-2616	GBM	TCGA	ANSTS	DEG_SPOP_SBC_1	0.8778
p.S91L	TCGA-D5-5541	COAD	TCGA	ANSTS	DEG_SPOP_SBC_1	0.8778
p.S91L	DO10475	COAD	ICGC	ANSTS	DEG_SPOP_SBC_1	0.8778
p.S91L	DO13462	GBM	ICGC	ANSTS	DEG_SPOP_SBC_1	0.8778
p.S91L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.8778
p.S91L	H513	pleura	COSMIC	ANSTS	DEG_SPOP_SBC_1	0.8778
p.S93Y	TCGA-55-8205	LUAD	TCGA	ANSTS	DEG_SPOP_SBC_1	0.7222
p.S93Y	DO48884	LUAD	ICGC	ANSTS	DEG_SPOP_SBC_1	0.7222
p.F84L	TCGA-AA-3977	COAD	TCGA	ANSTS	DEG_SPOP_SBC_1	0.25
p.F84L	TCGA-B5-A3FA	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.25
p.F84L	DO8730	COAD	ICGC	ANSTS	DEG_SPOP_SBC_1	0.25
p.F84L	DO229045	LICA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.25
p.F84L	DO52402	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.25
p.F78L	TCGA-EE-A185	SKCM	TCGA	ANSTS	DEG_SPOP_SBC_1	0.0833
p.F78L	DO222658	MELA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.0833
p.F78L	DO37599	SKCM	ICGC	ANSTS	DEG_SPOP_SBC_1	0.0833
p.T98M	DO233693	GACA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.5833
p.R86Q	DO35140	PACA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.3056
p.V94M	SIDM00845	Burkitt's Lymphoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0PJK1	Sodium/glucose cotransporter 5	DEG_SPOP_SBC_1	3:7	ANSTS	SPOP	0.522	More...
P22794	Protein EVI2A	DEG_SPOP_SBC_1	37:41	ANSTS	SPOP	0.9697	More...
P43121	Cell surface glycoprotein MUC18	DEG_SPOP_SBC_1	543:547	ANSTS	SPOP	0.9356	More...
Q6UXK2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	DEG_SPOP_SBC_1	363:367	ANSTS	SPOP	0.656	More...
Q9BTN0	Leucine-rich repeat and fibronectin type-III domain-containing protein 3	DEG_SPOP_SBC_1	392:396	ANSTS	SPOP	0.9888	More...
Q9UKI2	Cdc42 effector protein 3	DEG_SPOP_SBC_1	87:91	ANSTS	SPOP	0.9981	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	546:550	ANSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons