DegronMD

Uniprot ID: P22794

Source protein: Protein EVI2A

Source gene: EVI2A

Class: DEG_SPOP_SBC_1

Location: 37:41

E3 ligase: SPOP

DEGRON score: 0.9697

ASA_SCORE: 78.3

COIL: 0.7222

CONS_SCORE: 0.4621

DSS_SCORE: 0.2672

HELIX: 0.0386

FCONS_SCORE: 0.7784

RIG_SCORE: 0.7696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F39L	TCGA-61-2009	OV	TCGA	ANSTS	DEG_SPOP_SBC_1	0.6981
p.E29K	TCGA-BR-7901	STAD	TCGA	ANSTS	DEG_SPOP_SBC_1	0.2222
p.E29G	TCGA-BS-A0UV	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	0.2222
p.L40M	TCGA-DU-6392	LGG	TCGA	ANSTS	DEG_SPOP_SBC_1	0.711
p.T42A	TCGA-XK-AAIW	PRAD	TCGA	ANSTS	DEG_SPOP_SBC_1	0.3056
p.Q48E	DO51639	CESC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1389
p.N31K	DO229045	LICA	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1667
p.N31K	DO41133	UCEC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1667
p.I47T	DO223720	LUSC	ICGC	ANSTS	DEG_SPOP_SBC_1	0.1667
p.G27E	DO27851	MALY	ICGC	ANSTS	DEG_SPOP_SBC_1	0.0556
p.Y34C	SIDM02021	Esophageal Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.25
p.H36R	SIDM00078	Oral Cavity Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0PJK1	Sodium/glucose cotransporter 5	DEG_SPOP_SBC_1	3:7	ANSTS	SPOP	0.522	More...
P22794	Protein EVI2A	DEG_SPOP_SBC_1	37:41	ANSTS	SPOP	0.9697	More...
P43121	Cell surface glycoprotein MUC18	DEG_SPOP_SBC_1	543:547	ANSTS	SPOP	0.9356	More...
Q6UXK2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	DEG_SPOP_SBC_1	363:367	ANSTS	SPOP	0.656	More...
Q9BTN0	Leucine-rich repeat and fibronectin type-III domain-containing protein 3	DEG_SPOP_SBC_1	392:396	ANSTS	SPOP	0.9888	More...
Q9UKI2	Cdc42 effector protein 3	DEG_SPOP_SBC_1	87:91	ANSTS	SPOP	0.9981	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	546:550	ANSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons