DegronMD - P43121(MCAM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V440L	TCGA-23-2645	OV	TCGA	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.2778
p.P555S	TCGA-50-7109	LUAD	TCGA	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1111
p.P555S	DO24487	LUAD	ICGC	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1111
p.A537T	TCGA-AJ-A3BH	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1667
p.A454V	TCGA-AJ-A3EK	UCEC	TCGA	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1111
p.A454V	DO233154	GACA	ICGC	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1111
p.A454V	DO41584	UCEC	ICGC	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1111
p.A454V	SIDM01757	Bladder Carcinoma	GDSC	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1111
p.A454V	ACH-000741	Bladder Cancer	CCLE	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1111
p.P539S	TCGA-B5-A11E	UCEC	TCGA	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2222
p.R120C	TCGA-BR-6452	STAD	TCGA	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation rewiring degron network	0.0833
p.R120C	DO38404	STAD	ICGC	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation rewiring degron network	0.0833
p.E111K	TCGA-E7-A5KE	BLCA	TCGA	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation altering degron motif	0.7022
p.E111K	DO44048	BLCA	ICGC	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation altering degron motif	0.7022
p.E444D	TCGA-EO-A22R	UCEC	TCGA	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation altering degron motif	0.6758
p.E549D	TCGA-FS-A1ZG	SKCM	TCGA	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778
p.E549D	DO37523	SKCM	ICGC	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778
p.R112H	TCGA-L3-A524	LUSC	TCGA	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation rewiring degron network	0.3056
p.R112H	TCGA-VQ-A8P2	STAD	TCGA	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation rewiring degron network	0.3056
p.R112H	DO45476	LUSC	ICGC	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation rewiring degron network	0.3056
p.R112H	DO51761	STAD	ICGC	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation rewiring degron network	0.3056
p.E556D	TCGA-UY-A9PD	BLCA	TCGA	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0833
p.E556D	DO219042	BLCA	ICGC	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0833
p.G119V	DO227646	COCA	ICGC	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation substituting flanking lysine	0.2222
p.D453N	DO229005	COCA	ICGC	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1389
p.Q117K	DO228952	LICA	ICGC	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation rewiring degron network	0.1667
p.A99D	DO228976	LICA	ICGC	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation rewiring degron network	0.1389
p.V118M	DO220886	MELA	ICGC	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation rewiring degron network	0.1389
p.D114N	DO220886	MELA	ICGC	VTPQDE	DEG_SCF_FBW7_2	106:111	Mutation rewiring degron network	0.25
p.A450S	DO37531	SKCM	ICGC	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.2222
p.E440D	DO42568	UCEC	ICGC	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.2778
p.N434S	DO42673	UCEC	ICGC	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1111
p.T534I	SIDM01117	Small Cell Lung Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0833
p.T534I	ACH-002176	Lung Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0833
p.T534I	NCI-H748	lung	COSMIC	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0833
p.P555R	SIDM00705	Non-Cancerous	GDSC	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1111
p.P555R	SIDM00696	Non-Cancerous	GDSC	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1111
p.P555R	SIDM00772	Breast Carcinoma	GDSC	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1111
p.P555R	ACH-002369	Non-Cancerous	CCLE	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1111
p.P555R	ACH-002383	Non-Cancerous	CCLE	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1111
p.K439Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation substituting flanking lysine	0.3611
p.K439Q	H513	pleura	COSMIC	VKENM	DEG_APCC_KENBOX_2	442:446	Mutation substituting flanking lysine	0.3611
p.T534A	ACH-000306	Non-Cancerous	CCLE	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0833
p.S557R	ACH-000586	Lung Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0556
p.S557R	NCI-H1876	lung	COSMIC	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0556
p.T541S	ACH-001536	Bile Duct Cancer	CCLE	ANSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778

Kaplan plot for MCAM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCAM

UniProt ID: P43121

Entrez ID: 4162

Protein name: Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCAM in