DegronMD

Uniprot ID: P43121

Source protein: Cell surface glycoprotein MUC18

Source gene: MCAM

Class: DEG_APCC_KENBOX_2

Location: 442:446

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5244

ASA_SCORE: 82.08

COIL: 0.6022

CONS_SCORE: 0.6564

DSS_SCORE: 0.1528

HELIX: 0.006

FCONS_SCORE: 0.9502

RIG_SCORE: 0.9258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V440L	TCGA-23-2645	OV	TCGA	VKENM	DEG_APCC_KENBOX_2	0.2778
p.A454V	TCGA-AJ-A3EK	UCEC	TCGA	VKENM	DEG_APCC_KENBOX_2	0.1111
p.A454V	DO233154	GACA	ICGC	VKENM	DEG_APCC_KENBOX_2	0.1111
p.A454V	DO41584	UCEC	ICGC	VKENM	DEG_APCC_KENBOX_2	0.1111
p.A454V	SIDM01757	Bladder Carcinoma	GDSC	VKENM	DEG_APCC_KENBOX_2	0.1111
p.A454V	ACH-000741	Bladder Cancer	CCLE	VKENM	DEG_APCC_KENBOX_2	0.1111
p.E444D	TCGA-EO-A22R	UCEC	TCGA	VKENM	DEG_APCC_KENBOX_2	0.6758
p.D453N	DO229005	COCA	ICGC	VKENM	DEG_APCC_KENBOX_2	0.1389
p.A450S	DO37531	SKCM	ICGC	VKENM	DEG_APCC_KENBOX_2	0.2222
p.E440D	DO42568	UCEC	ICGC	VKENM	DEG_APCC_KENBOX_2	0.2778
p.N434S	DO42673	UCEC	ICGC	VKENM	DEG_APCC_KENBOX_2	0.1111
p.K439Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VKENM	DEG_APCC_KENBOX_2	0.3611
p.K439Q	H513	pleura	COSMIC	VKENM	DEG_APCC_KENBOX_2	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43121	Cell surface glycoprotein MUC18	DEG_APCC_KENBOX_2	442:446	VKENM	APC,CDC20,FZR1	0.5244	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons