DegronMD

Uniprot ID: P43121

Source protein: Cell surface glycoprotein MUC18

Source gene: MCAM

Class: DEG_SCF_FBW7_2

Location: 106:111

E3 ligase: FBXW7

DEGRON score: 0.6709

ASA_SCORE: 64.0167

COIL: 0.5713

CONS_SCORE: 0.6263

DSS_SCORE: 0.352

HELIX: 0.4098

FCONS_SCORE: 1.2274

RIG_SCORE: 0.8151

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R120C	TCGA-BR-6452	STAD	TCGA	VTPQDE	DEG_SCF_FBW7_2	0.0833
p.R120C	DO38404	STAD	ICGC	VTPQDE	DEG_SCF_FBW7_2	0.0833
p.E111K	TCGA-E7-A5KE	BLCA	TCGA	VTPQDE	DEG_SCF_FBW7_2	0.7022
p.E111K	DO44048	BLCA	ICGC	VTPQDE	DEG_SCF_FBW7_2	0.7022
p.R112H	TCGA-L3-A524	LUSC	TCGA	VTPQDE	DEG_SCF_FBW7_2	0.3056
p.R112H	TCGA-VQ-A8P2	STAD	TCGA	VTPQDE	DEG_SCF_FBW7_2	0.3056
p.R112H	DO45476	LUSC	ICGC	VTPQDE	DEG_SCF_FBW7_2	0.3056
p.R112H	DO51761	STAD	ICGC	VTPQDE	DEG_SCF_FBW7_2	0.3056
p.G119V	DO227646	COCA	ICGC	VTPQDE	DEG_SCF_FBW7_2	0.2222
p.Q117K	DO228952	LICA	ICGC	VTPQDE	DEG_SCF_FBW7_2	0.1667
p.A99D	DO228976	LICA	ICGC	VTPQDE	DEG_SCF_FBW7_2	0.1389
p.V118M	DO220886	MELA	ICGC	VTPQDE	DEG_SCF_FBW7_2	0.1389
p.D114N	DO220886	MELA	ICGC	VTPQDE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43121	Cell surface glycoprotein MUC18	DEG_SCF_FBW7_2	106:111	VTPQDE	FBXW7	0.6709	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons