DegronMD

Uniprot ID: Q6UXK2

Source protein: Immunoglobulin superfamily containing leucine-rich repeat protein 2

Source gene: ISLR2

Class: DEG_APCC_DBOX_1

Location: 523:531

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9515

ASA_SCORE: 70.9556

COIL: 0.5267

CONS_SCORE: 0.5309

DSS_SCORE: 0.315

HELIX: 0.0336

FCONS_SCORE: 1.358

RIG_SCORE: 0.8133

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P534L	TCGA-DD-AACG	LIHC	TCGA	GRRPLRLLY	DEG_APCC_DBOX_1	0.25
p.P534L	DO52202	LIHC	ICGC	GRRPLRLLY	DEG_APCC_DBOX_1	0.25
p.G537S	DO50541	BOCA	ICGC	GRRPLRLLY	DEG_APCC_DBOX_1	0.1667
p.R528C	DO220828	BRCA	ICGC	GRRPLRLLY	DEG_APCC_DBOX_1	0.719
p.G515R	DO229256	LMS	ICGC	GRRPLRLLY	DEG_APCC_DBOX_1	0.1111
p.A535V	SIDM01307	Colorectal Carcinoma	GDSC	GRRPLRLLY	DEG_APCC_DBOX_1	0.2222
p.L527M	SIDM00118	Colorectal Carcinoma	GDSC	GRRPLRLLY	DEG_APCC_DBOX_1	0.711
p.L532V	ACH-001412	Bladder Cancer	CCLE	GRRPLRLLY	DEG_APCC_DBOX_1	0.3056
p.Y531F	ACH-002041	Thyroid Cancer	CCLE	GRRPLRLLY	DEG_APCC_DBOX_1	0.6417

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXK2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	DEG_APCC_DBOX_1	523:531	GRRPLRLLY	APC,CDC20,FZR1	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons