DegronMD

Uniprot ID: Q6UXK2

Source protein: Immunoglobulin superfamily containing leucine-rich repeat protein 2

Source gene: ISLR2

Class: DEG_APCC_DBOX_1

Location: 498:506

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8197

ASA_SCORE: 57.2444

COIL: 0.4683

CONS_SCORE: 0.5506

DSS_SCORE: 0.3497

HELIX: 0.2127

FCONS_SCORE: 1.2815

RIG_SCORE: 0.8103

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R508C	TCGA-AN-A0FW	BRCA	TCGA	ARVQLTPLA	DEG_APCC_DBOX_1	0.2778
p.R508C	DO2825	BRCA	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	0.2778
p.A490V	TCGA-D3-A8GM	SKCM	TCGA	ARVQLTPLA	DEG_APCC_DBOX_1	0.1111
p.A490V	DO50288	SKCM	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	0.1111
p.E497K	TCGA-IB-A6UG	PAAD	TCGA	ARVQLTPLA	DEG_APCC_DBOX_1	0.3056
p.E497K	DO225209	BRCA	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	0.3056
p.E497K	DO49414	PAAD	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	0.3056
p.E497K	SIDM00589	Oral Cavity Carcinoma	GDSC	ARVQLTPLA	DEG_APCC_DBOX_1	0.3056
p.E497K	ACH-000778	Head and Neck Cancer	CCLE	ARVQLTPLA	DEG_APCC_DBOX_1	0.3056
p.E497K	HSC-3	upper_aerodigestive_tract	COSMIC	ARVQLTPLA	DEG_APCC_DBOX_1	0.3056
p.E495K	DO1076	BRCA	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	0.25
p.A494V	DO222454	BTCA	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	0.2222
p.A494V	ACH-001719	Ovarian Cancer	CCLE	ARVQLTPLA	DEG_APCC_DBOX_1	0.2222
p.G515R	DO229256	LMS	ICGC	ARVQLTPLA	DEG_APCC_DBOX_1	0.0833
p.A506T	SIDM00241	Breast Carcinoma	GDSC	ARVQLTPLA	DEG_APCC_DBOX_1	0.6028
p.W509R	ACH-000842	Colon/Colorectal Cancer	CCLE	ARVQLTPLA	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXK2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	DEG_APCC_DBOX_1	498:506	ARVQLTPLA	APC,CDC20,FZR1	0.8197	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons