DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_SCF_FBW7_1

Location: 524:530

E3 ligase: FBXW7

DEGRON score: 0.9899

ASA_SCORE: 99.9

COIL: 0.9623

CONS_SCORE: 0.3957

DSS_SCORE: 0.5192

HELIX: 0.0139

FCONS_SCORE: 0.7926

RIG_SCORE: 0.6574

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A520P	TCGA-05-4427	LUAD	TCGA	IPTPQRT	DEG_SCF_FBW7_1	0.2222
p.S522L	TCGA-2Y-A9H5	LIHC	TCGA	IPTPQRT	DEG_SCF_FBW7_1	0.2778
p.A520S	TCGA-53-7813	LUAD	TCGA	IPTPQRT	DEG_SCF_FBW7_1	0.2222
p.G540V	TCGA-69-7978	LUAD	TCGA	IPTPQRT	DEG_SCF_FBW7_1	0.0556
p.G540D	TCGA-B5-A3FC	UCEC	TCGA	IPTPQRT	DEG_SCF_FBW7_1	0.0556
p.L537M	TCGA-D1-A103	UCEC	TCGA	IPTPQRT	DEG_SCF_FBW7_1	0.1389
p.A523S	TCGA-EA-A3HS	CESC	TCGA	IPTPQRT	DEG_SCF_FBW7_1	0.3056
p.Q528H	TCGA-EE-A2MM	SKCM	TCGA	IPTPQRT	DEG_SCF_FBW7_1	0.647
p.Y519H	TCGA-EI-6882	READ	TCGA	IPTPQRT	DEG_SCF_FBW7_1	0.1944
p.P521L	TCGA-YS-A95C	MESO	TCGA	IPTPQRT	DEG_SCF_FBW7_1	0.25
p.G518V	DO24920	LUAD	ICGC	IPTPQRT	DEG_SCF_FBW7_1	0.1667
p.T529I	DO222708	MELA	ICGC	IPTPQRT	DEG_SCF_FBW7_1	0.7078
p.S537F	DO37667	SKCM	ICGC	IPTPQRT	DEG_SCF_FBW7_1	0.1389
p.P538L	DO51277	SKCM	ICGC	IPTPQRT	DEG_SCF_FBW7_1	0.1111
p.L515M	DO42312	UCEC	ICGC	IPTPQRT	DEG_SCF_FBW7_1	0.0833
p.A540V	DO223286	UCEC	ICGC	IPTPQRT	DEG_SCF_FBW7_1	0.0556
p.G518D	DO41871	UCEC	ICGC	IPTPQRT	DEG_SCF_FBW7_1	0.1667
p.P534H	LIM1215	large_intestine	COSMIC	IPTPQRT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XN7	Proline and serine-rich protein 1	DEG_SCF_FBW7_1	524:530	IPTPQRT	FBXW7	0.9899	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons