DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_ODPH_VHL_1

Location: 212:225

E3 ligase: VHL

DEGRON score: 0.9551

ASA_SCORE: 76.4571

COIL: 0.9072

CONS_SCORE: 0.7227

DSS_SCORE: 0.3633

HELIX: 0.0461

FCONS_SCORE: 0.9605

RIG_SCORE: 0.7168

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P214S	TCGA-37-5819	LUSC	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.6752
p.H209R	TCGA-AA-A02E	COAD	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.25
p.P202L	TCGA-AX-A06F	UCEC	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.0556
p.P202L	TCGA-AX-A2HD	UCEC	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.0556
p.A226V	TCGA-EO-A22U	UCEC	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.A226V	SIDM00403	T-Lymphoblastic Leukemia	GDSC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.A226V	ACH-000636	Leukemia	CCLE	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.A226V	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.R207Q	TCGA-QN-A5NN	UCS	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1944
p.I207T	DO6353	CLLE	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1944
p.D225N	DO233720	GACA	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.6932
p.P210T	DO229022	LICA	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.2778
p.P209Q	DO229027	LICA	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.25
p.Y214C	DO44806	LICA	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.7087
p.P211S	DO24200	LUAD	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.S230L	DO222837	MELA	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1944
p.S227L	DO41644	UCEC	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.2778
p.S227L	DO43755	UCEC	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.2778
p.S227L	HT-115	large_intestine	COSMIC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.2778
p.A204V	DO43755	UCEC	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1111
p.A204V	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1111
p.P204R	SIDM01042	Breast Carcinoma	GDSC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1111
p.P204R	ACH-001065	Breast Cancer	CCLE	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1111
p.P204R	EVSA-T	breast	COSMIC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1111
p.T211A	SIDM01435	Hepatocellular Carcinoma	GDSC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.D225G	A172	central_nervous_system	COSMIC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.7198

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPSAYNNAGLVPL

Degron related mutations and impact score

Drug responses associated with PROSER1 mutations

All proteins holding degron of IAPSAYNNAGLVPL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XN7	Proline and serine-rich protein 1	DEG_ODPH_VHL_1	212:225	IAPSAYNNAGLVPL	VHL	0.9551	More...