DegronMD

Uniprot ID: Q86XN7

Source protein: Proline and serine-rich protein 1

Source gene: PROSER1

Class: DEG_ODPH_VHL_1

Location: 212:225

E3 ligase: VHL

DEGRON score: 0.9551

ASA_SCORE: 76.4571

COIL: 0.9072

CONS_SCORE: 0.7227

DSS_SCORE: 0.3633

HELIX: 0.0461

FCONS_SCORE: 0.9605

RIG_SCORE: 0.7168

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D225G	A172	central_nervous_system	COSMIC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.7198
p.Y214C	DO44806	LICA	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.7087
p.D225N	DO233720	GACA	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.6932
p.P214S	TCGA-37-5819	LUSC	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.6752
p.A226V	TCGA-EO-A22U	UCEC	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.A226V	SIDM00403	T-Lymphoblastic Leukemia	GDSC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.A226V	ACH-000636	Leukemia	CCLE	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.A226V	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.P211S	DO24200	LUAD	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.T211A	SIDM01435	Hepatocellular Carcinoma	GDSC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.3056
p.P210T	DO229022	LICA	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.2778
p.S227L	DO41644	UCEC	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.2778
p.S227L	DO43755	UCEC	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.2778
p.S227L	HT-115	large_intestine	COSMIC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.2778
p.H209R	TCGA-AA-A02E	COAD	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.25
p.P209Q	DO229027	LICA	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.25
p.R207Q	TCGA-QN-A5NN	UCS	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1944
p.I207T	DO6353	CLLE	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1944
p.S230L	DO222837	MELA	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1944
p.A204V	DO43755	UCEC	ICGC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1111
p.A204V	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1111
p.P204R	SIDM01042	Breast Carcinoma	GDSC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1111
p.P204R	ACH-001065	Breast Cancer	CCLE	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1111
p.P204R	EVSA-T	breast	COSMIC	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.1111
p.P202L	TCGA-AX-A06F	UCEC	TCGA	IAPSAYNNAGLVPL	DEG_ODPH_VHL_1	0.0556

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Drug responses associated with PROSER1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of IAPSAYNNAGLVPL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XN7	Proline and serine-rich protein 1	DEG_ODPH_VHL_1	212:225	IAPSAYNNAGLVPL	VHL	0.9551	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPSAYNNAGLVPL

Degron related mutations and impact score

Drug responses associated with PROSER1 mutations

All proteins holding degron of IAPSAYNNAGLVPL