DegronMD

Uniprot ID: P52594

Source protein: Arf-GAP domain and FG repeat-containing protein 1

Source gene: AGFG1

Class: DEG_SPOP_SBC_1

Location: 444:448

E3 ligase: SPOP

DEGRON score: 0.937

ASA_SCORE: 69.64

COIL: 0.8996

CONS_SCORE: 0.2722

DSS_SCORE: 0.4576

HELIX: 0.0414

FCONS_SCORE: 0.8619

RIG_SCORE: 0.665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V434M	TCGA-19-5956	GBM	TCGA	VASST	DEG_SPOP_SBC_1	0.0556
p.A453G	TCGA-22-1012	LUSC	TCGA	VASST	DEG_SPOP_SBC_1	0.1944
p.T454M	TCGA-IB-7651	PAAD	TCGA	VASST	DEG_SPOP_SBC_1	0.1667
p.F451C	TCGA-W5-AA39	CHOL	TCGA	VASST	DEG_SPOP_SBC_1	0.25
p.M449I	DO8842	COAD	ICGC	VASST	DEG_SPOP_SBC_1	0.3056
p.T451I	DO230342	COCA	ICGC	VASST	DEG_SPOP_SBC_1	0.25
p.M447L	DO233034	GACA	ICGC	VASST	DEG_SPOP_SBC_1	0.711
p.A457P	DO219178	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	0.0833
p.S448G	DO47743	STAD	ICGC	VASST	DEG_SPOP_SBC_1	0.6993
p.P456L	DO42097	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.1111
p.M449T	DO42913	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.3056
p.N458I	SIDM00533	Pancreatic Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.0556
p.N458I	HuP-T3	pancreas	COSMIC	VASST	DEG_SPOP_SBC_1	0.0556
p.P456A	ACH-000136	Neuroblastoma	CCLE	VASST	DEG_SPOP_SBC_1	0.1111
p.P456A	CHP-126	autonomic_ganglia	COSMIC	VASST	DEG_SPOP_SBC_1	0.1111
p.Q452H	TC-YIK	cervix	COSMIC	VASST	DEG_SPOP_SBC_1	0.2222
p.N434I	HuP-T3	pancreas	COSMIC	VASST	DEG_SPOP_SBC_1	0.0556
p.P439S	Sarc9371	bone	COSMIC	VASST	DEG_SPOP_SBC_1	0.1944
p.P458S	Sarc9371	bone	COSMIC	VASST	DEG_SPOP_SBC_1	0.0556
p.P437A	CHP-126	autonomic_ganglia	COSMIC	VASST	DEG_SPOP_SBC_1	0.1389
p.A439V	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	VASST	DEG_SPOP_SBC_1	0.1944
p.F436C	HCC2998	large_intestine	COSMIC	VASST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	208:212	VASST	SPOP	0.6543	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	34:38	VASST	SPOP	0.9984	More...
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	366:370	VASST	SPOP	0.601	More...
P35789	Zinc finger protein 93	DEG_SPOP_SBC_1	435:439	VASST	SPOP	0.6657	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	444:448	VASST	SPOP	0.937	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	1971:1975	VASST	SPOP	0.9917	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	860:864	VASST	SPOP	0.9989	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	110:114	VASST	SPOP	0.9912	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	862:866	VASST	SPOP	0.9864	More...
Q9H4H8	Protein FAM83D	DEG_SPOP_SBC_1	487:491	VASST	SPOP	0.9868	More...
Q9UHD8	Septin-9	DEG_SPOP_SBC_1	56:60	VASST	SPOP	0.9944	More...
Q9UI36	Dachshund homolog 1	DEG_SPOP_SBC_1	128:132	VASST	SPOP	0.9985	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2007:2011	VASST	SPOP	0.9246	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1380:1384	VASST	SPOP	0.9098	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	46:50	VASST	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons