DegronMD

Uniprot ID: Q9H2X6

Source protein: Homeodomain-interacting protein kinase 2

Source gene: HIPK2

Class: DEG_SPOP_SBC_1

Location: 862:866

E3 ligase: SPOP

DEGRON score: 0.9864

ASA_SCORE: 75.82

COIL: 0.8144

CONS_SCORE: 0.3222

DSS_SCORE: 0.4749

HELIX: 0.0804

FCONS_SCORE: 0.9454

RIG_SCORE: 0.7518

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R870W	TCGA-AX-A3FT	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	0.2222
p.R870W	DO40801	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.2222
p.C857S	TCGA-LG-A9QC	LIHC	TCGA	VASST	DEG_SPOP_SBC_1	0.1944
p.C857S	DO49701	LIHC	ICGC	VASST	DEG_SPOP_SBC_1	0.1944
p.D861H	DO45037	LINC	ICGC	VASST	DEG_SPOP_SBC_1	0.3056
p.D861N	DO46360	OV	ICGC	VASST	DEG_SPOP_SBC_1	0.3056
p.T866A	DO229446	SKCA	ICGC	VASST	DEG_SPOP_SBC_1	0.7139
p.R868W	SIDM00351	Oral Cavity Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.2778
p.R868W	SIDM01782	Oral Cavity Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.2778
p.R868W	SAS	upper_aerodigestive_tract	COSMIC	VASST	DEG_SPOP_SBC_1	0.2778
p.I875V	SIDM00864	Cervical Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.0833
p.I875V	ACH-001341	Cervical Cancer	CCLE	VASST	DEG_SPOP_SBC_1	0.0833
p.I875V	DoTc2-4510	cervix	COSMIC	VASST	DEG_SPOP_SBC_1	0.0833
p.V862M	ACH-001518	Endometrial/Uterine Cancer	CCLE	VASST	DEG_SPOP_SBC_1	0.7208
p.E869K	SNU-1040	large_intestine	COSMIC	VASST	DEG_SPOP_SBC_1	0.25

Drug responses associated with HIPK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.E136D (No)	GDSC	PI-103	186.6479
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D502N (No)	GDSC	PI-103	1.081
SIDM00951	LAML\|acute_myeloid_leukaemia	p.I227T (No)	GDSC	PI-103	1.081
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G1184V (No)	GDSC	PI-103	0.1231
SIDM00680	COREAD\|large_intestine	p.R554Q (No)	GDSC	PI-103	131.335
SIDM01045	UCEC\|endometrium	p.L59fs*56 (No)	GDSC	PI-103	3.7811
SIDM00499	PRAD\|prostate	p.G45D (No)	GDSC	PI-103	0.3537
SIDM00145	ALL\|lymphoblastic_leukemia	p.N914K (No)	GDSC	PI-103	0.1685
SIDM00108	SKCM\|melanoma	p.H322Q (No)	GDSC	PI-103	2.1752
SIDM00351	HNSC\|head_and_neck	p.R868W (Yes)	GDSC	PI-103	1.0036
SIDM00976	SKCM\|melanoma	p.G348R (No)	GDSC	PI-103	0.2229
SIDM00045	STAD\|stomach	p.C658F (No)	GDSC	PI-103	0.7557
SIDM01107	SKCM\|melanoma	p.T602P (No)	GDSC	PI-103	57.4273
SIDM01007	ALL\|lymphoblastic_leukemia	p.H807R (No)	GDSC	PI-103	0.2023
SIDM01007	ALL\|lymphoblastic_leukemia	p.K805R (No)	GDSC	PI-103	0.2023
SIDM01073	UNCLASSIFIED\|hairy_cell_leukaemia	p.S142N (No)	GDSC	PI-103	0.2031
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.H760R (No)	GDSC	PI-103	2.0651
SIDM00565	HNSC\|head_and_neck	p.V737M (No)	GDSC	PI-103	2.2952
SIDM00443	DLBC\|B_cell_lymphoma	p.R941C (No)	GDSC	PI-103	0.0219
SIDM00377	UNCLASSIFIED\|uterus	p.H540R (No)	GDSC	PI-103	2.6284
SIDM00498	COREAD\|large_intestine	p.I603V (No)	GDSC	PI-103	3.2887
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.A624V (No)	GDSC	PI-103	0.0783
SIDM01045	UCEC\|endometrium	p.V94E (No)	GDSC	PI-103	3.7811
SIDM00946	ALL\|T_cell_leukemia	p.V50M (No)	GDSC	PI-103	0.526
SIDM00864	CESC\|cervix	p.I875V (Yes)	GDSC	PI-103	23.1182
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.R433S (No)	GDSC	PI-103	131.0205
SIDM00217	COREAD\|large_intestine	p.A1178V (No)	GDSC	PI-103	1.8634
SIDM00217	COREAD\|large_intestine	p.E896K (No)	GDSC	PI-103	1.8634
SIDM01003	ALL\|lymphoblastic_leukemia	p.R497Q (No)	GDSC	PI-103	0.2158
SIDM00216	COREAD\|large_intestine	p.I146T (No)	GDSC	PI-103	20.9452
SIDM00596	UCEC\|endometrium	p.R498Q (No)	GDSC	PI-103	22.6646
SIDM00282	COREAD\|large_intestine	p.A719S (No)	GDSC	PI-103	28.6572
SIDM00660	COREAD\|large_intestine	p.A512V (No)	GDSC	PI-103	0.5852
SIDM00955	SKCM\|melanoma	p.T1022N (No)	GDSC	PI-103	14.8056
SIDM00783	COREAD\|large_intestine	p.R792W (No)	GDSC	PI-103	0.5867
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I33V (No)	GDSC	PI-103	0.0974
SIDM00789	COREAD\|large_intestine	p.V67I (No)	GDSC	PI-103	0.8427
SIDM00534	COREAD\|large_intestine	p.V1121A (No)	GDSC	PI-103	137.3337
SIDM00149	SKCM\|melanoma	p.M635I (No)	GDSC	PI-103	3.9173
SIDM00545	SKCM\|melanoma	p.R1056Q (No)	GDSC	PI-103	9.7833
SIDM00545	SKCM\|melanoma	p.H524Y (No)	GDSC	PI-103	9.7833
SIDM00114	MESO\|mesothelioma	p.L716I (No)	GDSC	PI-103	6.8017
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R133H (No)	GDSC	PI-103	0.976
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L108F (No)	GDSC	PI-103	0.2536
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.S317I (No)	GDSC	PI-103	17.6642
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.F500V (No)	GDSC	PI-103	1.0649
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y468N (No)	GDSC	PI-103	1.0649
SIDM00537	COREAD\|large_intestine	p.T125A (No)	GDSC	PI-103	32.6383
SIDM00799	GBM\|glioma	p.S1002Y (No)	GDSC	PI-103	54.1746
SIDM00496	THCA\|thyroid	p.Q747K (No)	GDSC	PI-103	0.4742
SIDM00878	BRCA\|breast	p.R833C (No)	GDSC	PI-103	0.1835

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	208:212	VASST	SPOP	0.6543	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	34:38	VASST	SPOP	0.9984	More...
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	366:370	VASST	SPOP	0.601	More...
P35789	Zinc finger protein 93	DEG_SPOP_SBC_1	435:439	VASST	SPOP	0.6657	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	444:448	VASST	SPOP	0.937	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	1971:1975	VASST	SPOP	0.9917	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	860:864	VASST	SPOP	0.9989	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	110:114	VASST	SPOP	0.9912	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	862:866	VASST	SPOP	0.9864	More...
Q9H4H8	Protein FAM83D	DEG_SPOP_SBC_1	487:491	VASST	SPOP	0.9868	More...
Q9UHD8	Septin-9	DEG_SPOP_SBC_1	56:60	VASST	SPOP	0.9944	More...
Q9UI36	Dachshund homolog 1	DEG_SPOP_SBC_1	128:132	VASST	SPOP	0.9985	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2007:2011	VASST	SPOP	0.9246	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1380:1384	VASST	SPOP	0.9098	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	46:50	VASST	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASST

Degron related mutations and impact score

Drug responses associated with HIPK2 mutations

All proteins holding degron of VASST