DegronMD

Uniprot ID: Q9Y4G8

Source protein: Rap guanine nucleotide exchange factor 2

Source gene: RAPGEF2

Class: DEG_SPOP_SBC_1

Location: 1380:1384

E3 ligase: SPOP

DEGRON score: 0.9098

ASA_SCORE: 57.38

COIL: 0.7064

CONS_SCORE: 0.3206

DSS_SCORE: 0.5255

HELIX: 0.08

FCONS_SCORE: 1.0751

RIG_SCORE: 0.7268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1390S	TCGA-46-3768	LUSC	TCGA	VASST	DEG_SPOP_SBC_1	0.1667
p.A1390S	DO26466	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	0.1667
p.A1379S	TCGA-A5-A0G2	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	0.3056
p.A1379S	DO41235	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.3056
p.A1379S	SIDM01387	Small Cell Lung Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.3056
p.A1379S	ACH-000921	Lung Cancer	CCLE	VASST	DEG_SPOP_SBC_1	0.3056
p.H1377L	TCGA-CJ-4901	KIRC	TCGA	VASST	DEG_SPOP_SBC_1	0.25
p.H1377L	DO16276	KIRC	ICGC	VASST	DEG_SPOP_SBC_1	0.25
p.H1377L	DO35549	PBCA	ICGC	VASST	DEG_SPOP_SBC_1	0.25
p.P1373L	TCGA-W3-A825	SKCM	TCGA	VASST	DEG_SPOP_SBC_1	0.1389
p.P1373L	DO51272	SKCM	ICGC	VASST	DEG_SPOP_SBC_1	0.1389
p.G1394C	DO229036	LICA	ICGC	VASST	DEG_SPOP_SBC_1	0.0556
p.A1381V	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.5825
p.A1381V	NCI-H3122	lung	COSMIC	VASST	DEG_SPOP_SBC_1	0.5825
p.S1381T	NCI-H23	lung	COSMIC	VASST	DEG_SPOP_SBC_1	0.7116
p.S1389Y	LNCaP-Clone-FGC	prostate	COSMIC	VASST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	208:212	VASST	SPOP	0.6543	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	34:38	VASST	SPOP	0.9984	More...
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	366:370	VASST	SPOP	0.601	More...
P35789	Zinc finger protein 93	DEG_SPOP_SBC_1	435:439	VASST	SPOP	0.6657	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	444:448	VASST	SPOP	0.937	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	1971:1975	VASST	SPOP	0.9917	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	860:864	VASST	SPOP	0.9989	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	110:114	VASST	SPOP	0.9912	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	862:866	VASST	SPOP	0.9864	More...
Q9H4H8	Protein FAM83D	DEG_SPOP_SBC_1	487:491	VASST	SPOP	0.9868	More...
Q9UHD8	Septin-9	DEG_SPOP_SBC_1	56:60	VASST	SPOP	0.9944	More...
Q9UI36	Dachshund homolog 1	DEG_SPOP_SBC_1	128:132	VASST	SPOP	0.9985	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2007:2011	VASST	SPOP	0.9246	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1380:1384	VASST	SPOP	0.9098	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	46:50	VASST	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons