DegronMD - P10071(GLI3)

GO - Biological processes (BP): anterior/posterior pattern specification [GO:0009952]; anterior semicircular canal development [GO:0060873]; artery development [GO:0060840]; axon guidance [GO:0007411]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye morphogenesis [GO:0048593]; cell differentiation involved in kidney development [GO:0061005]; developmental growth [GO:0048589]; embryonic digestive tract development [GO:0048566]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic neurocranium morphogenesis [GO:0048702]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain radial glial cell differentiation [GO:0021861]; frontal suture morphogenesis [GO:0060364]; heart development [GO:0007507]; hindgut morphogenesis [GO:0007442]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; lambdoid suture morphogenesis [GO:0060366]; larynx morphogenesis [GO:0120223]; lateral ganglionic eminence cell proliferation [GO:0022018]; lateral semicircular canal development [GO:0060875]; layer formation in cerebral cortex [GO:0021819]; limb morphogenesis [GO:0035108]; liver regeneration [GO:0097421]; lung development [GO:0030324]; mammary gland specification [GO:0060594]; melanocyte differentiation [GO:0030318]; metanephros development [GO:0001656]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hh target transcription factor activity [GO:1990787]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative thymic T cell selection [GO:0045060]; nose morphogenesis [GO:0043585]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; optic nerve morphogenesis [GO:0021631]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; protein processing [GO:0016485]; proximal/distal pattern formation [GO:0009954]; regulation of bone development [GO:1903010]; regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901620]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; roof of mouth development [GO:0060021]; sagittal suture morphogenesis [GO:0060367]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; T cell differentiation in thymus [GO:0033077]; thymocyte apoptotic process [GO:0070242]; tongue development [GO:0043586]; vocalization behavior [GO:0071625]; wound healing [GO:0042060] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q670E	TCGA-13-0893	OV	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.0556
p.Q670E	DO29002	OV	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.0556
p.R1542L	TCGA-17-Z049	LUAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7316
p.Q661H	TCGA-35-3615	LUAD	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.3056
p.Q661H	DO23627	LUAD	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.3056
p.P653L	TCGA-37-4130	LUSC	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.P653L	TCGA-BS-A0TJ	UCEC	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.P653L	TCGA-F1-6874	STAD	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.P653L	DO234335	ESAD	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.P653L	DO26490	LUSC	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.P653L	DO38201	STAD	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.P653L	DO42953	UCEC	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.P653L	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.P653L	ACH-000916	Lung Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.P653L	NCI-H1573	lung	COSMIC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.A161S	TCGA-44-2657	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7588
p.A161S	DO25020	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7588
p.Y168F	TCGA-55-A4DG	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation blocking phosphorylation signal	0.6944
p.Y168F	DO26337	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation blocking phosphorylation signal	0.6944
p.P651Q	TCGA-86-6851	LUAD	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2222
p.P651Q	DO23798	LUAD	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2222
p.S37N	TCGA-A5-A0G1	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	34:38	Mutation altering degron motif	0.7069
p.S37N	DO42472	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation altering degron motif	0.7069
p.I197T	TCGA-A5-A1OF	UCEC	TCGA	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.7078
p.I197T	DO42568	UCEC	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.7078
p.P429L	TCGA-AA-3815	COAD	TCGA	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.25
p.P429L	DO9924	COAD	ICGC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.25
p.P429L	SIDM01962	Colorectal Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.25
p.R205H	TCGA-AA-A022	COAD	TCGA	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.25
p.R205H	TCGA-AX-A2HD	UCEC	TCGA	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.25
p.R205H	DO10647	COAD	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.25
p.R205H	DO42608	UCEC	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.25
p.T167M	TCGA-AG-3592	READ	TCGA	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2778
p.T167M	DO50399	ESAD	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2778
p.T167M	DO233109	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2778
p.T167M	DO37308	READ	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2778
p.E81K	TCGA-AG-A002	READ	TCGA	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2778
p.E81K	TCGA-BT-A20R	BLCA	TCGA	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2778
p.E81K	DO622	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2778
p.D655Y	TCGA-AJ-A5DW	UCEC	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation altering degron motif	0.7325
p.D655Y	DO50075	UCEC	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation altering degron motif	0.7325
p.R26Q	TCGA-AJ-A5DW	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1111
p.R26Q	TCGA-BS-A0UV	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1111
p.R26Q	DO35128	PACA	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1111
p.R26Q	DO50075	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1111
p.R26Q	DO42793	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1111
p.S36F	TCGA-AP-A051	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	34:38	Mutation altering degron motif	0.7982
p.S36F	DO42673	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation altering degron motif	0.7982
p.D28N	TCGA-AP-A1DV	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1667
p.D28N	DO43186	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1667
p.R1542W	TCGA-AZ-4615	COAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7523
p.R1542W	DO7977	COAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7523
p.R1542W	DO233737	GACA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7523
p.A1549V	TCGA-B5-A3FC	UCEC	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.A1549V	TCGA-EI-6917	READ	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.A1549V	DO36881	READ	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.A1549V	DO41871	UCEC	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.A1549V	SIDM00251	Gastric Carcinoma	GDSC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.A1549V	ACH-000949	Gastric Cancer	CCLE	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.A1549V	TGBC11TKB	stomach	COSMIC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.A1543G	TCGA-BK-A139	UCEC	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.6429
p.A1543G	DO41716	UCEC	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.6429
p.P152L	TCGA-BR-8297	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.P152L	TCGA-DF-A2KU	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.P152L	DO233245	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.P152L	DO38555	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.P152L	DO223286	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.L833I	TCGA-BS-A0UV	UCEC	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation altering degron motif	0.7174
p.L833I	DO42793	UCEC	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation altering degron motif	0.7174
p.F190I	TCGA-CC-A5UD	LIHC	TCGA	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1389
p.F190I	DO219552	LIHC	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1389
p.P192H	TCGA-CM-6170	COAD	TCGA	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1944
p.P192H	DO7849	COAD	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1944
p.R1537H	TCGA-CM-6677	COAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.3056
p.R1537H	TCGA-DM-A0XD	COAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.3056
p.R1537H	TCGA-HU-8243	STAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.3056
p.R1537H	DO10228	COAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.3056
p.R1537H	DO8570	COAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.3056
p.R1537H	DO47915	STAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.3056
p.D28A	TCGA-D1-A17Q	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1667
p.D28A	DO41903	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1667
p.S834F	TCGA-D3-A2JP	SKCM	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation altering degron motif	0.6871
p.S834F	DO47407	SKCM	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation altering degron motif	0.6871
p.P195L	TCGA-D3-A51R	SKCM	TCGA	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.2778
p.P195L	DO49149	PACA	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.2778
p.P195L	DO47480	SKCM	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.2778
p.L826F	TCGA-D3-A8GM	SKCM	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.25
p.L826F	DO50288	SKCM	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.25
p.T825M	TCGA-D5-6926	COAD	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.2222
p.T825M	DO8530	COAD	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.2222
p.T825M	DO234239	ESAD	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.2222
p.L827I	TCGA-D7-A4Z0	STAD	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.2778
p.L827I	DO47765	STAD	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.2778
p.P652L	TCGA-EB-A430	SKCM	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.25
p.P652L	DO37906	SKCM	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.25
p.R649W	TCGA-EE-A2MR	SKCM	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1667
p.R649W	TCGA-VS-A958	CESC	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1667
p.R649W	DO51639	CESC	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1667
p.R649W	DO37819	SKCM	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1667
p.S664L	TCGA-EI-6917	READ	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation blocking phosphorylation signal	0.6667
p.S664L	DO36881	READ	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation blocking phosphorylation signal	0.6667
p.S664L	SIDM00228	Thyroid Gland Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation blocking phosphorylation signal	0.6667
p.S664L	ACH-000897	Thyroid Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation blocking phosphorylation signal	0.6667
p.S160F	TCGA-ER-A42K	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056
p.S160F	DO220891	MELA	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056
p.S160F	DO51252	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056
p.G829D	TCGA-F1-6874	STAD	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation altering degron motif	0.6087
p.G829D	DO38201	STAD	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation altering degron motif	0.6087
p.P199S	TCGA-FR-A8YC	SKCM	TCGA	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.6752
p.P199S	DO50301	SKCM	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.6752
p.P828L	TCGA-HF-7132	STAD	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.3056
p.P828L	DO38214	STAD	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.3056
p.P169L	TCGA-HU-A4GC	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.P169L	DO230314	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.P169L	DO233251	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.P169L	DO228142	PBCA	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.P169L	DO47797	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.S1551C	TCGA-L5-A8NR	ESCA	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1389
p.A1549E	TCGA-L9-A7SV	LUAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.A1549E	DO49875	LUAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.1944
p.H647Y	TCGA-NC-A5HE	LUSC	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1111
p.H647Y	DO45453	LUSC	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1111
p.S1553G	TCGA-ND-A4WF	UCS	TCGA	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.0833
p.R175K	TCGA-VQ-A8P2	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0556
p.R175K	DO51761	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0556
p.P653Q	TCGA-VQ-AA6K	STAD	TCGA	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.P653Q	DO222401	STAD	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.T1540M	DO224768	BRCA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7423
p.T1540M	DO50398	ESAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7423
p.D428N	DO222541	BTCA	ICGC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2778
p.D70N	DO228935	COCA	ICGC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation substituting flanking lysine	0.3056
p.D832N	DO227985	COCA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation altering degron motif	0.5821
p.D74G	DO234285	ESAD	ICGC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.3056
p.T418S	DO233134	GACA	ICGC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2222
p.K436T	DO233107	GACA	ICGC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation substituting flanking lysine	0.1667
p.R663S	DO233271	GACA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.25
p.S209G	DO233624	GACA	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1389
p.P650L	DO233760	GACA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1944
p.P650Q	DO231942	LICA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1944
p.A83G	DO228456	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2222
p.P172A	DO228921	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1389
p.C67Y	DO228947	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1111
p.P417T	DO228952	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.1944
p.S188Y	DO228971	LICA	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.0833
p.T839N	DO228971	LICA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.2778
p.S24Y	DO229019	LICA	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.0556
p.S209R	DO229029	LICA	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1389
p.D837E	DO229026	LICA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation altering degron motif	0.5647
p.S191R	DO229031	LICA	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1667
p.P648T	DO229036	LICA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1389
p.T1540K	DO229035	LICA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7306
p.T825K	DO229038	LICA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.2222
p.N69K	DO229037	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1667
p.N415K	DO229041	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.1389
p.D170E	DO229045	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1944
p.P653S	DO50970	LICA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.2778
p.Q670P	DO50927	LICA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.0556
p.S435Y	DO45139	LIRI	ICGC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.0833
p.D43N	DO230990	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1944
p.D43N	DO224554	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1944
p.S45G	DO228600	MALY	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation blocking phosphorylation signal	0.5833
p.P828Q	DO222731	MELA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.3056
p.T418M	DO30060	OV	ICGC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2222
p.R205C	DO34696	PACA	ICGC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.25
p.M840T	DO224575	PACA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.25
p.S1535F	DO232224	PBCA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.25
p.S1535F	DO229479	SKCA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.25
p.A1543T	DO229240	THCA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.6028
p.A47D	DO42673	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.0833
p.R649Q	SIDM00582	Pancreatic Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1667
p.R649Q	ACH-000281	Pancreatic Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1667
p.R649Q	KP-2	pancreas	COSMIC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1667
p.V71I	SIDM00458	Acute Myeloid Leukemia	GDSC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2222
p.V71I	SIDM00735	Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2222
p.V71I	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2222
p.V71I	NCI-H2029	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2222
p.P199L	SIDM00007	Other Solid Cancers	GDSC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.6471
p.P199L	ACH-001550	Skin Cancer	CCLE	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.6471
p.P199L	MCC13	skin	COSMIC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.6471
p.G47V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.0833
p.G47V	ACH-000945	Lung Cancer	CCLE	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.0833
p.G47V	NCI-H650	lung	COSMIC	VASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.0833
p.R649L	SIDM00357	Small Cell Lung Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1667
p.R649L	ACH-002193	Lung Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1667
p.R649L	RERF-LC-FM	lung	COSMIC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1667
p.S421F	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.3056
p.S421F	ACH-000951	Lung Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.3056
p.S421F	NCI-H2342	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.3056
p.Y200C	SIDM00217	Colorectal Carcinoma	GDSC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.7087
p.Y200C	ACH-000999	Colon/Colorectal Cancer	CCLE	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.7087
p.Y200C	SNU-1040	large intestine	COSMIC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.7087
p.N842D	SIDM00359	Colorectal Carcinoma	GDSC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.1944
p.N842D	ACH-000565	Colon/Colorectal Cancer	CCLE	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.1944
p.N842D	RCM-1	large intestine	COSMIC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.1944
p.L1545P	SIDM01662	Plasma Cell Myeloma	GDSC	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.3056
p.L1545P	ACH-000564	Myeloma	CCLE	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation rewiring degron network	0.3056
p.V838I	SIDM01588	Endometrial Carcinoma	GDSC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.3056
p.V838I	ACH-000993	Endometrial/Uterine Cancer	CCLE	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.3056
p.R667L	SIDM00497	Colorectal Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1389
p.R667L	ACH-000683	Colon/Colorectal Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation rewiring degron network	0.1389
p.T1540A	ACH-000665	Lung Cancer	CCLE	LTTPRAS	DEG_SCF_FBW7_1	1538:1544	Mutation altering degron motif	0.7139
p.L833F	ACH-001389	Breast Cancer	CCLE	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation altering degron motif	0.6981
p.P827L	GP5d	large intestine	COSMIC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.2778
p.H73Y	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2778
p.R189C	Sarc9371	bone	COSMIC	INPYMD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1111
p.R845H	MES-SA	soft tissue	COSMIC	GRSDLSGVD	DEG_APCC_DBOX_1	829:837	Mutation rewiring degron network	0.1111
p.L669F	LS-411N	large intestine	COSMIC	DSGSHS	DEG_SCF_TRCP1_1	655:660	Mutation blocking phosphorylation signal	0.5278

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLI3

UniProt ID: P10071

Entrez ID: 2737

Protein name: Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLI3 in