DegronMD

Uniprot ID: P10071

Source protein: Transcriptional activator GLI3

Source gene: GLI3

Class: DEG_SPOP_SBC_1

Location: 161:165

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 51.66

COIL: 0.847

CONS_SCORE: 0.4032

DSS_SCORE: 0.4715

HELIX: 0.1098

FCONS_SCORE: 1.0204

RIG_SCORE: 0.6074

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A161S	TCGA-44-2657	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.7588
p.A161S	DO25020	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.7588
p.Y168F	TCGA-55-A4DG	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.6944
p.Y168F	DO26337	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.6944
p.S160F	TCGA-ER-A42K	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	0.3056
p.S160F	DO220891	MELA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.3056
p.S160F	DO51252	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	0.3056
p.T167M	TCGA-AG-3592	READ	TCGA	ALSSS	DEG_SPOP_SBC_1	0.2778
p.T167M	DO50399	ESAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.2778
p.T167M	DO233109	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.2778
p.T167M	DO37308	READ	ICGC	ALSSS	DEG_SPOP_SBC_1	0.2778
p.P169L	TCGA-HU-A4GC	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.2222
p.P169L	DO230314	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.2222
p.P169L	DO233251	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.2222
p.P169L	DO228142	PBCA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.2222
p.P169L	DO47797	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.2222
p.D170E	DO229045	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1944
p.P172A	DO228921	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.P152L	TCGA-BR-8297	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.0833
p.P152L	TCGA-DF-A2KU	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	0.0833
p.P152L	DO233245	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.0833
p.P152L	DO38555	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.0833
p.P152L	DO223286	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	0.0833
p.R175K	TCGA-VQ-A8P2	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.0556
p.R175K	DO51761	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.0556

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Drug responses associated with GLI3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ALSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_SPOP_SBC_1	1260:1264	ALSSS	SPOP	0.7764	More...
P53999	Activated RNA polymerase II transcriptional coactivator p15	DEG_SPOP_SBC_1	48:52	ALSSS	SPOP	0.9949	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	272:276	ALSSS	SPOP	0.9996	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	909:913	ALSSS	SPOP	0.9517	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	486:490	ALSSS	SPOP	0.9813	More...
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SPOP_SBC_1	271:275	ALSSS	SPOP	0.9811	More...
Q53ET0	CREB-regulated transcription coactivator 2	DEG_SPOP_SBC_1	396:400	ALSSS	SPOP	0.9946	More...
Q70SY1	Cyclic AMP-responsive element-binding protein 3-like protein 2	DEG_SPOP_SBC_1	245:249	ALSSS	SPOP	0.9922	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	2049:2053	ALSSS	SPOP	0.9596	More...
Q16531	DNA damage-binding protein 1	DEG_SPOP_SBC_1	760:764	ALSSS	SPOP	0.9918	More...
Q8IXT1	DNA damage-induced apoptosis suppressor protein	DEG_SPOP_SBC_1	541:545	ALSSS	SPOP	0.9938	More...
Q56P03	E2F-associated phosphoprotein	DEG_SPOP_SBC_1	22:26	ALSSS	SPOP	0.96	More...
Q06587	E3 ubiquitin-protein ligase RING1	DEG_SPOP_SBC_1	136:140	ALSSS	SPOP	0.9879	More...
Q52LR7	Enhancer of polycomb homolog 2	DEG_SPOP_SBC_1	684:688	ALSSS	SPOP	0.9033	More...
O14681	Etoposide-induced protein 2.4 homolog	DEG_SPOP_SBC_1	314:318	ALSSS	SPOP	0.7903	More...
Q86X51	EZH inhibitory protein	DEG_SPOP_SBC_1	59:63	ALSSS	SPOP	0.8892	More...
Q99501	GAS2-like protein 1	DEG_SPOP_SBC_1	597:601	ALSSS	SPOP	0.9987	More...
Q9UFP1	Golgi-associated kinase 1A	DEG_SPOP_SBC_1	63:67	ALSSS	SPOP	0.9976	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	803:807	ALSSS	SPOP	0.8649	More...
Q6DN90	IQ motif and SEC7 domain-containing protein 1	DEG_SPOP_SBC_1	921:925	ALSSS	SPOP	0.9622	More...
Q5JU85	IQ motif and SEC7 domain-containing protein 2	DEG_SPOP_SBC_1	1139:1143	ALSSS	SPOP	0.7552	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1730:1734	ALSSS	SPOP	0.9832	More...
P48681	Nestin	DEG_SPOP_SBC_1	1448:1452	ALSSS	SPOP	0.968	More...
Q9H2A3	Neurogenin-2	DEG_SPOP_SBC_1	200:204	ALSSS	SPOP	0.923	More...
Q8NEJ9	Neuroguidin	DEG_SPOP_SBC_1	200:204	ALSSS	SPOP	0.9753	More...

Showing 1 to 25 of 42 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALSSS

Degron related mutations and impact score

Drug responses associated with GLI3 mutations

All proteins holding degron of ALSSS