DegronMD - Q6DN90(IQSEC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G933W	TCGA-38-4625	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1111
p.G933W	DO23952	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1111
p.E182D	TCGA-A3-A6NL	KIRC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1667
p.E182D	DO50458	KIRC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1667
p.R158C	TCGA-A5-A0GH	UCEC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.R158C	DO43634	UCEC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.R158C	ACH-000965	Endometrial/Uterine Cancer	CCLE	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.R158C	RL95-2	endometrium	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.R927W	TCGA-AX-A1CE	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2778
p.R927W	DO42280	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2778
p.S173F	TCGA-AX-A2HD	UCEC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.6871
p.S173F	DO42608	UCEC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.6871
p.P184H	TCGA-BF-A1PZ	SKCM	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1111
p.P184H	DO50279	SKCM	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1111
p.G183E	TCGA-BF-AAOX	SKCM	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1389
p.G183E	DO223907	SKCM	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1389
p.A912V	TCGA-CK-4951	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.0833
p.A912V	DO10582	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.0833
p.R919H	TCGA-EC-A24G	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2778
p.R919H	DO233236	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2778
p.R919H	DO40996	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2778
p.R169Q	TCGA-EO-A22R	UCEC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7329
p.R169Q	DO42713	UCEC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7329
p.R158H	TCGA-ER-A42H	SKCM	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.R158H	TCGA-L5-A4OE	ESCA	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.R158H	DO223909	SKCM	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.R158H	ACH-001459	Colon/Colorectal Cancer	CCLE	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.S930L	TCGA-F1-6177	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1944
p.S930L	DO38727	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1944
p.S925F	TCGA-FR-A8YC	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.9093
p.S925F	DO50301	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.9093
p.R165H	TCGA-PG-A917	UCEC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.25
p.R165H	DO52424	UCEC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.25
p.E163Q	TCGA-UF-A7JT	HNSC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1944
p.E163Q	DO219090	HNSC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1944
p.R168C	DO230342	COCA	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.719
p.S913R	DO228926	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation blocking phosphorylation signal	0.5556
p.L929I	DO229019	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.R165S	DO230530	LUSC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.25
p.R158L	DO46330	OV	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.R927L	DO229264	THCA	ICGC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2778
p.V173A	SIDM00151	Ovarian Carcinoma	GDSC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.6936
p.V173A	IGROV-1	ovary	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.6936
p.N933T	SIDM01042	Breast Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1111
p.N933T	EVSA-T	breast	COSMIC	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1111
p.A921T	ACH-000997	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7139
p.A921T	ACH-001061	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7139
p.M166T	ACH-000999	Colon/Colorectal Cancer	CCLE	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2778
p.M166T	SNU-1040	large intestine	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2778
p.R159C	RL95-2	endometrium	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0833
p.M167T	SNU-1040	large intestine	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation blocking phosphorylation signal	0.75
p.E158K	SNU-398	liver	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.E158K	TC-YIK	cervix	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.M166V	SNU-423	liver	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2778

Kaplan plot for IQSEC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IQSEC1

UniProt ID: Q6DN90

Entrez ID: 9922

Protein name: IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IQSEC1 in