DegronMD

Uniprot ID: Q6DN90

Source protein: IQ motif and SEC7 domain-containing protein 1

Source gene: IQSEC1

Class: DEG_APCC_DBOX_1

Location: 168:176

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9788

ASA_SCORE: 95.6444

COIL: 0.6042

CONS_SCORE: 0.4009

DSS_SCORE: 0.3809

HELIX: 0.2511

FCONS_SCORE: 1.0623

RIG_SCORE: 0.7899

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E182D	TCGA-A3-A6NL	KIRC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	0.1667
p.E182D	DO50458	KIRC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.1667
p.R158C	TCGA-A5-A0GH	UCEC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.R158C	DO43634	UCEC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.R158C	ACH-000965	Endometrial/Uterine Cancer	CCLE	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.R158C	RL95-2	endometrium	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.S173F	TCGA-AX-A2HD	UCEC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	0.6871
p.S173F	DO42608	UCEC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.6871
p.P184H	TCGA-BF-A1PZ	SKCM	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	0.1111
p.P184H	DO50279	SKCM	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.1111
p.G183E	TCGA-BF-AAOX	SKCM	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	0.1389
p.G183E	DO223907	SKCM	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.1389
p.R169Q	TCGA-EO-A22R	UCEC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	0.7329
p.R169Q	DO42713	UCEC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.7329
p.R158H	TCGA-ER-A42H	SKCM	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.R158H	TCGA-L5-A4OE	ESCA	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.R158H	DO223909	SKCM	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.R158H	ACH-001459	Colon/Colorectal Cancer	CCLE	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.R165H	TCGA-PG-A917	UCEC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	0.25
p.R165H	DO52424	UCEC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.25
p.E163Q	TCGA-UF-A7JT	HNSC	TCGA	RRIVLSNMR	DEG_APCC_DBOX_1	0.1944
p.E163Q	DO219090	HNSC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.1944
p.R168C	DO230342	COCA	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.719
p.R165S	DO230530	LUSC	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.25
p.R158L	DO46330	OV	ICGC	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.V173A	SIDM00151	Ovarian Carcinoma	GDSC	RRIVLSNMR	DEG_APCC_DBOX_1	0.6936
p.V173A	IGROV-1	ovary	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	0.6936
p.M166T	ACH-000999	Colon/Colorectal Cancer	CCLE	RRIVLSNMR	DEG_APCC_DBOX_1	0.2778
p.M166T	SNU-1040	large_intestine	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	0.2778
p.R159C	RL95-2	endometrium	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	0.0833
p.M167T	SNU-1040	large_intestine	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	0.75
p.E158K	SNU-398	liver	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.E158K	TC-YIK	cervix	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	0.0556
p.M166V	SNU-423	liver	COSMIC	RRIVLSNMR	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRIVLSNMR

Degron related mutations and impact score

Drug responses associated with IQSEC1 mutations

All proteins holding degron of RRIVLSNMR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6DN90	IQ motif and SEC7 domain-containing protein 1	DEG_APCC_DBOX_1	168:176	RRIVLSNMR	APC,CDC20,FZR1	0.9788	More...