DegronMD - Q53ET0(CRTC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D443Y	TCGA-49-4487	LUAD	TCGA	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.1389
p.D443Y	DO24780	LUAD	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.1389
p.R429H	TCGA-A6-2686	COAD	TCGA	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation altering degron motif	0.8244
p.R429H	DO7828	COAD	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation altering degron motif	0.8244
p.D443N	TCGA-AA-A01R	COAD	TCGA	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.1389
p.D443N	DO7934	COAD	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.1389
p.D443N	SIDM00118	Colorectal Carcinoma	GDSC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.1389
p.R428C	TCGA-AZ-6601	COAD	TCGA	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation altering degron motif	0.719
p.R428C	DO8119	COAD	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation altering degron motif	0.719
p.S402F	TCGA-BS-A0U7	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.2778
p.S402F	TCGA-ER-A19G	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.2778
p.S402F	TCGA-Z2-A8RT	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.2778
p.S402F	DO47284	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.2778
p.S402F	DO51301	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.2778
p.S402F	DO41482	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.2778
p.A439V	TCGA-CM-6162	COAD	TCGA	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.25
p.A439V	DO8479	COAD	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.25
p.T406N	TCGA-ER-A19P	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1667
p.T406N	DO47623	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1667
p.S436G	DO229337	BTCA	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation altering degron motif	0.6993
p.S393N	DO230347	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation blocking phosphorylation signal	0.6944
p.A413T	DO50341	ESAD	ICGC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation rewiring degron network	0.2222
p.A423G	DO228390	LICA	ICGC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation altering degron motif	0.6429
p.A423G	DO52365	LUSC	ICGC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation altering degron motif	0.6429
p.A423G	SIDM00216	Colorectal Carcinoma	GDSC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation altering degron motif	0.6429
p.A423G	SIDM01194	Hepatocellular Carcinoma	GDSC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation altering degron motif	0.6429
p.A423G	SIDM00162	Biliary Tract Carcinoma	GDSC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation altering degron motif	0.6429
p.A423G	SNU-175	large intestine	COSMIC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation altering degron motif	0.6429
p.A423G	SNU-449	liver	COSMIC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation altering degron motif	0.6429
p.H427N	DO228976	LICA	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.3056
p.H427N	DO228976	LICA	ICGC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation rewiring degron network	0.25
p.H426Q	DO228985	LICA	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.2778
p.H426Q	DO228985	LICA	ICGC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation rewiring degron network	0.2778
p.P441T	DO229037	LICA	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.1944
p.H389N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1389
p.H389N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1389
p.T406S	SIDM00392	Melanoma	GDSC	ALSSS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1667
p.A442T	SIDM00122	Breast Carcinoma	GDSC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.1667
p.A442T	BT-549	breast	COSMIC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.1667
p.H426N	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.2778
p.H426N	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation rewiring degron network	0.2778
p.H426N	MC116	haematopoietic and lymphoid tissue	COSMIC	RRVPLSPLS	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.2778
p.H426N	MC116	haematopoietic and lymphoid tissue	COSMIC	PASTPGAS	DEG_SCF_FBW7_1	417:424	Mutation rewiring degron network	0.2778

Kaplan plot for CRTC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CRTC2

UniProt ID: Q53ET0

Entrez ID: 200186

Protein name: CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CRTC2 in