DegronMD

Uniprot ID: Q53ET0

Source protein: CREB-regulated transcription coactivator 2

Source gene: CRTC2

Class: DEG_APCC_DBOX_1

Location: 428:436

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9351

ASA_SCORE: 94.9667

COIL: 0.9213

CONS_SCORE: 0.4407

DSS_SCORE: 0.618

HELIX: 0.0398

FCONS_SCORE: 0.9245

RIG_SCORE: 0.6751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D443Y	TCGA-49-4487	LUAD	TCGA	RRVPLSPLS	DEG_APCC_DBOX_1	0.1389
p.D443Y	DO24780	LUAD	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	0.1389
p.R429H	TCGA-A6-2686	COAD	TCGA	RRVPLSPLS	DEG_APCC_DBOX_1	0.8244
p.R429H	DO7828	COAD	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	0.8244
p.D443N	TCGA-AA-A01R	COAD	TCGA	RRVPLSPLS	DEG_APCC_DBOX_1	0.1389
p.D443N	DO7934	COAD	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	0.1389
p.D443N	SIDM00118	Colorectal Carcinoma	GDSC	RRVPLSPLS	DEG_APCC_DBOX_1	0.1389
p.R428C	TCGA-AZ-6601	COAD	TCGA	RRVPLSPLS	DEG_APCC_DBOX_1	0.719
p.R428C	DO8119	COAD	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	0.719
p.A439V	TCGA-CM-6162	COAD	TCGA	RRVPLSPLS	DEG_APCC_DBOX_1	0.25
p.A439V	DO8479	COAD	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	0.25
p.S436G	DO229337	BTCA	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	0.6993
p.H427N	DO228976	LICA	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	0.3056
p.H426Q	DO228985	LICA	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	0.2778
p.P441T	DO229037	LICA	ICGC	RRVPLSPLS	DEG_APCC_DBOX_1	0.1944
p.A442T	SIDM00122	Breast Carcinoma	GDSC	RRVPLSPLS	DEG_APCC_DBOX_1	0.1667
p.A442T	BT-549	breast	COSMIC	RRVPLSPLS	DEG_APCC_DBOX_1	0.1667
p.H426N	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRVPLSPLS	DEG_APCC_DBOX_1	0.2778
p.H426N	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	RRVPLSPLS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53ET0	CREB-regulated transcription coactivator 2	DEG_APCC_DBOX_1	428:436	RRVPLSPLS	APC,CDC20,FZR1	0.9351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons