DegronMD

Uniprot ID: Q53ET0

Source protein: CREB-regulated transcription coactivator 2

Source gene: CRTC2

Class: DEG_SCF_FBW7_1

Location: 417:424

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 73.4375

COIL: 0.9583

CONS_SCORE: 0.5035

DSS_SCORE: 0.6388

HELIX: 0.0153

FCONS_SCORE: 1.1554

RIG_SCORE: 0.5098

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A413T	DO50341	ESAD	ICGC	PASTPGAS	DEG_SCF_FBW7_1	0.2222
p.A423G	DO228390	LICA	ICGC	PASTPGAS	DEG_SCF_FBW7_1	0.6429
p.A423G	DO52365	LUSC	ICGC	PASTPGAS	DEG_SCF_FBW7_1	0.6429
p.A423G	SIDM00216	Colorectal Carcinoma	GDSC	PASTPGAS	DEG_SCF_FBW7_1	0.6429
p.A423G	SIDM01194	Hepatocellular Carcinoma	GDSC	PASTPGAS	DEG_SCF_FBW7_1	0.6429
p.A423G	SIDM00162	Biliary Tract Carcinoma	GDSC	PASTPGAS	DEG_SCF_FBW7_1	0.6429
p.A423G	SNU-175	large_intestine	COSMIC	PASTPGAS	DEG_SCF_FBW7_1	0.6429
p.A423G	SNU-449	liver	COSMIC	PASTPGAS	DEG_SCF_FBW7_1	0.6429
p.H427N	DO228976	LICA	ICGC	PASTPGAS	DEG_SCF_FBW7_1	0.25
p.H426Q	DO228985	LICA	ICGC	PASTPGAS	DEG_SCF_FBW7_1	0.2778
p.H426N	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	PASTPGAS	DEG_SCF_FBW7_1	0.2778
p.H426N	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	PASTPGAS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53ET0	CREB-regulated transcription coactivator 2	DEG_SCF_FBW7_1	417:424	PASTPGAS	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons