DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_SPOP_SBC_1

Location: 803:807

E3 ligase: SPOP

DEGRON score: 0.8649

ASA_SCORE: 71.24

COIL: 0.8456

CONS_SCORE: 0.2435

DSS_SCORE: 0.4147

HELIX: 0.1264

FCONS_SCORE: 0.9094

RIG_SCORE: 0.6419

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T814S	TCGA-12-1093	GBM	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1389
p.T814S	DO14097	GBM	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.A803S	TCGA-17-Z014	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.7588
p.M796L	TCGA-53-7626	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1389
p.M796L	DO23774	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.M796L	LN-405	central_nervous_system	COSMIC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.P813A	TCGA-67-3771	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1667
p.P813A	DO25797	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1667
p.M812I	TCGA-73-A9RS	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1944
p.M812I	TCGA-CN-A63W	HNSC	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1944
p.M812I	TCGA-V1-A9OT	PRAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1944
p.M812I	DO49031	HNSC	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1944
p.M812I	DO51193	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1944
p.M812I	DO219385	PRAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1944
p.S793L	TCGA-A5-A2K7	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	0.0556
p.S793L	TCGA-AZ-4315	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.0556
p.S793L	DO8842	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.0556
p.S793L	DO41271	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	0.0556
p.S793L	SIDM01588	Endometrial Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	0.0556
p.S793L	MCC26	skin	COSMIC	ALSSS	DEG_SPOP_SBC_1	0.0556
p.H798R	TCGA-AG-3891	READ	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1944
p.H798R	DO36388	READ	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1944
p.S806P	TCGA-B5-A11E	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	0.6752
p.S806P	DO41644	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	0.6752
p.S802L	TCGA-BT-A3PH	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	0.3056
p.S802L	DO856	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.3056
p.S805R	TCGA-CS-5397	LGG	TCGA	ALSSS	DEG_SPOP_SBC_1	0.7427
p.S805R	DO22336	LGG	ICGC	ALSSS	DEG_SPOP_SBC_1	0.7427
p.S806F	TCGA-D3-A3ML	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	0.7982
p.S806F	TCGA-ER-A199	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	0.7982
p.S806F	DO47413	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	0.7982
p.S806F	DO47395	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	0.7982
p.A803D	TCGA-EO-A3AY	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	0.7793
p.A803D	DO43202	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	0.7793
p.H798D	TCGA-FD-A3NA	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1944
p.H798D	DO602	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1944
p.P801S	TCGA-FW-A3R5	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	0.2778
p.P801S	DO37406	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	0.2778
p.S807Y	TCGA-ND-A4WC	UCS	TCGA	ALSSS	DEG_SPOP_SBC_1	0.712
p.T815I	DO222842	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1111
p.L804V	DO50723	ORCA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.5654
p.L804V	HSC-39	stomach	COSMIC	ALSSS	DEG_SPOP_SBC_1	0.5654
p.L804V	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	0.5654
p.L804V	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	0.5654
p.L804V	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	0.5654
p.M796V	SIDM01278	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.A803P	SIDM00960	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	0.6392
p.P813S	SIDM00367	Small Cell Lung Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	0.1667
p.M796I	SIDM00837	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.M796I	ACH-000958	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	0.1389
p.M796I	SW48	large_intestine	COSMIC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.I811V	SIDM00431	T-Lymphoblastic Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	0.2222
p.I811V	SIDM01664	Prostate Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	0.2222
p.T814R	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.P801H	HCC-15	lung	COSMIC	ALSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14681	Etoposide-induced protein 2.4 homolog	DEG_SPOP_SBC_1	314:318	ALSSS	SPOP	0.7903	More...
P04049	RAF proto-oncogene serine/threonine-protein kinase	DEG_SPOP_SBC_1	292:296	ALSSS	SPOP	0.9009	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	161:165	ALSSS	SPOP	0.9989	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	123:127	ALSSS	SPOP	0.9284	More...
P48681	Nestin	DEG_SPOP_SBC_1	1448:1452	ALSSS	SPOP	0.968	More...
P53999	Activated RNA polymerase II transcriptional coactivator p15	DEG_SPOP_SBC_1	48:52	ALSSS	SPOP	0.9949	More...
Q01804	OTU domain-containing protein 4	DEG_SPOP_SBC_1	472:476	ALSSS	SPOP	0.9961	More...
Q06587	E3 ubiquitin-protein ligase RING1	DEG_SPOP_SBC_1	136:140	ALSSS	SPOP	0.9879	More...
Q13342	Nuclear body protein SP140	DEG_SPOP_SBC_1	181:185	ALSSS	SPOP	0.969	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1717:1721	ALSSS	SPOP	0.9305	More...
Q16531	DNA damage-binding protein 1	DEG_SPOP_SBC_1	760:764	ALSSS	SPOP	0.9918	More...
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_SPOP_SBC_1	1260:1264	ALSSS	SPOP	0.7764	More...
Q53ET0	CREB-regulated transcription coactivator 2	DEG_SPOP_SBC_1	396:400	ALSSS	SPOP	0.9946	More...
Q56P03	E2F-associated phosphoprotein	DEG_SPOP_SBC_1	22:26	ALSSS	SPOP	0.96	More...
Q5JU85	IQ motif and SEC7 domain-containing protein 2	DEG_SPOP_SBC_1	1139:1143	ALSSS	SPOP	0.7552	More...
Q5SXM2	snRNA-activating protein complex subunit 4	DEG_SPOP_SBC_1	1129:1133	ALSSS	SPOP	0.8944	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	717:721	ALSSS	SPOP	0.9122	More...
Q68D10	Protein SPT2 homolog	DEG_SPOP_SBC_1	276:280	ALSSS	SPOP	0.6856	More...
Q6DN90	IQ motif and SEC7 domain-containing protein 1	DEG_SPOP_SBC_1	921:925	ALSSS	SPOP	0.9622	More...
Q6EMK4	Vasorin	DEG_SPOP_SBC_1	370:374	ALSSS	SPOP	0.8789	More...
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SPOP_SBC_1	271:275	ALSSS	SPOP	0.9811	More...
Q70SY1	Cyclic AMP-responsive element-binding protein 3-like protein 2	DEG_SPOP_SBC_1	245:249	ALSSS	SPOP	0.9922	More...
Q7Z739	YTH domain-containing family protein 3	DEG_SPOP_SBC_1	211:215	ALSSS	SPOP	0.9258	More...
Q86X51	EZH inhibitory protein	DEG_SPOP_SBC_1	59:63	ALSSS	SPOP	0.8892	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	486:490	ALSSS	SPOP	0.9813	More...
Q8NEJ9	Neuroguidin	DEG_SPOP_SBC_1	200:204	ALSSS	SPOP	0.9753	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	803:807	ALSSS	SPOP	0.8649	More...
Q8TF30	WASP homolog-associated protein with actin, membranes and microtubules	DEG_SPOP_SBC_1	661:665	ALSSS	SPOP	0.9388	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1730:1734	ALSSS	SPOP	0.9832	More...
Q99501	GAS2-like protein 1	DEG_SPOP_SBC_1	597:601	ALSSS	SPOP	0.9987	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	2049:2053	ALSSS	SPOP	0.9596	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	414:418	ALSSS	SPOP	0.9785	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	272:276	ALSSS	SPOP	0.9996	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	909:913	ALSSS	SPOP	0.9517	More...
Q9UFP1	Golgi-associated kinase 1A	DEG_SPOP_SBC_1	63:67	ALSSS	SPOP	0.9976	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	1625:1629	ALSSS	SPOP	0.9778	More...
Q9UKJ1	Paired immunoglobulin-like type 2 receptor alpha	DEG_SPOP_SBC_1	273:277	ALSSS	SPOP	0.9986	More...
Q52LR7	Enhancer of polycomb homolog 2	DEG_SPOP_SBC_1	684:688	ALSSS	SPOP	0.9033	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	320:324	ALSSS	SPOP	0.9947	More...
Q8IXT1	DNA damage-induced apoptosis suppressor protein	DEG_SPOP_SBC_1	541:545	ALSSS	SPOP	0.9938	More...
Q9H2A3	Neurogenin-2	DEG_SPOP_SBC_1	200:204	ALSSS	SPOP	0.923	More...
Q9P242	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2	DEG_SPOP_SBC_1	409:413	ALSSS	SPOP	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALSSS

Degron related mutations and impact score

Drug responses associated with KMT2C mutations

All proteins holding degron of ALSSS