DegronMD - Q52LR7(EPC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S688I	TCGA-35-4123	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7341
p.S688I	DO26394	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7341
p.M683I	TCGA-38-4625	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.3056
p.M683I	DO23952	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.3056
p.P689S	TCGA-AB-2828	LAML	TCGA	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.3056
p.P689S	DO21571	LAML	ICGC	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.3056
p.E788K	TCGA-AX-A05Z	UCEC	TCGA	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.2778
p.E788K	TCGA-DU-6392	LGG	TCGA	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.2778
p.E788K	DO22237	LGG	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.2778
p.E788K	DO40884	UCEC	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.2778
p.S688N	TCGA-BM-6198	READ	TCGA	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7069
p.S688N	DO36978	READ	ICGC	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7069
p.N786S	TCGA-CG-4460	STAD	TCGA	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.2222
p.N786S	DO38427	STAD	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.2222
p.S680F	TCGA-EE-A2MJ	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2222
p.S680F	DO38099	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2222
p.A783E	DO222723	COCA	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.1389
p.P789L	DO220891	MELA	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.3056
p.I797M	DO47753	STAD	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation altering degron motif	0.6507
p.Y679C	SIDM02050	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1944
p.T674P	SIDM00845	Burkitt's Lymphoma	GDSC	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.T674P	SIDM01519	Head and Neck Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.T674P	ACH-000037	Sarcoma	CCLE	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.T674P	Daudi	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.A803T	SIDM00488	Colorectal Carcinoma	GDSC	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.1944
p.A803T	ACH-002345	Colon/Colorectal Cancer	CCLE	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.1944
p.A803T	CaR-1	large intestine	COSMIC	ERLGLNGIA	DEG_APCC_DBOX_1	790:798	Mutation rewiring degron network	0.1944

Kaplan plot for EPC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPC2

UniProt ID: Q52LR7

Entrez ID: 26122

Protein name: Enhancer of polycomb homolog 2 (EPC-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPC2 in