DegronMD

Uniprot ID: Q52LR7

Source protein: Enhancer of polycomb homolog 2

Source gene: EPC2

Class: DEG_APCC_DBOX_1

Location: 790:798

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8991

ASA_SCORE: 71.8333

COIL: 0.7606

CONS_SCORE: 0.3581

DSS_SCORE: 0.5273

HELIX: 0.1673

FCONS_SCORE: 0.9847

RIG_SCORE: 0.7125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E788K	TCGA-AX-A05Z	UCEC	TCGA	ERLGLNGIA	DEG_APCC_DBOX_1	0.2778
p.E788K	TCGA-DU-6392	LGG	TCGA	ERLGLNGIA	DEG_APCC_DBOX_1	0.2778
p.E788K	DO22237	LGG	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	0.2778
p.E788K	DO40884	UCEC	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	0.2778
p.N786S	TCGA-CG-4460	STAD	TCGA	ERLGLNGIA	DEG_APCC_DBOX_1	0.2222
p.N786S	DO38427	STAD	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	0.2222
p.A783E	DO222723	COCA	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	0.1389
p.P789L	DO220891	MELA	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	0.3056
p.I797M	DO47753	STAD	ICGC	ERLGLNGIA	DEG_APCC_DBOX_1	0.6507
p.A803T	SIDM00488	Colorectal Carcinoma	GDSC	ERLGLNGIA	DEG_APCC_DBOX_1	0.1944
p.A803T	ACH-002345	Colon/Colorectal Cancer	CCLE	ERLGLNGIA	DEG_APCC_DBOX_1	0.1944
p.A803T	CaR-1	large_intestine	COSMIC	ERLGLNGIA	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q52LR7	Enhancer of polycomb homolog 2	DEG_APCC_DBOX_1	790:798	ERLGLNGIA	APC,CDC20,FZR1	0.8991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons